BRSK1 抗体 (Internal Region)
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- 抗原 See all BRSK1 抗体
- BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BRSK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- BRSK1 Antibody detects endogenous levels of total BRSK1.
- 预测反应
- Pig,Bovine,Horse,Sheep,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human BRSK1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product BRSK1 Primary Antibody
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anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 426-591) antibody
BRSK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) (AA 355-384) antibodyBRSK1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40234 unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) antibody (Atto 488)BRSK1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488
anti-BR Serine/threonine Kinase 1 (BRSK1) antibody (Atto 594)BRSK1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 594
anti-BR Serine/threonine Kinase 1 (BRSK1) antibody (Atto 390)BRSK1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 390
anti-BR Serine/threonine Kinase 1 (BRSK1) (N-Term) antibodyBRSK1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-BR Serine/threonine Kinase 1 (BRSK1) antibody (HRP)BRSK1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal HRP
anti-BR Serine/threonine Kinase 1 (BRSK1) antibody (FITC)BRSK1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal FITC
anti-BR Serine/threonine Kinase 1 (BRSK1) antibody (Biotin)BRSK1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Biotin
anti-BR Serine/threonine Kinase 1 (BRSK1) antibody (PerCP)BRSK1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal PerCP
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
- 别名
- BRSK1 (BRSK1 产品)
- 别名
- BRSK1 antibody, hSAD1 antibody, Gm1100 antibody, SAD-B antibody, SADB antibody, RGD1563268 antibody, Sad-b antibody, BR serine/threonine kinase 1 antibody, BRSK1 antibody, Brsk1 antibody
- 背景
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Description: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
Gene: BRSK1
- 分子量
- 87 kDa
- 基因ID
- 84446
- UniProt
- Q8TDC3
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