anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) 抗体

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. 再加上,我们可以发Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
APPL1 290537  

antibodies-online.cn销售最多的anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 抗体

Showing 10 out of 69 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-APPL1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: THP-1 cell lysate 100 μL Log in to see 5至7个工作日
¥20,898.73
详细
山羊 非结合性 ELISA, WB ABIN190879 (0.5µg/ml) staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL1 adenovirus for 48hrs. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 100 μg Log in to see 24至29个工作日
¥9,230.97
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Cow 山羊 非结合性 WB   0.1 mg Log in to see 30至37个工作日
¥3,065.96
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山羊 非结合性 ELISA, WB Western Blot: APPL1 Antibody [ABIN252906] - APPL1 expression level after adenovirus transfection in rat aortic smooth muscle cells detected by ABIN252906. Western Blot: APPL Antibody [ABIN2529061] - Staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL adenovirus for 48hrs using ABIN2529061 at 0.5ug/ml. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 0.1 mg Log in to see 25至31个工作日
¥3,333.96
详细
Cow 非结合性 IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 29至35个工作日
¥6,705.77
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小鼠 非结合性 ICC, IF, IHC (p), IP, WB 50 μL Log in to see 25至30个工作日
¥4,817.71
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非结合性 WB Western Blot: APPL Antibody [NBP2-15433] - Sample (50 ug of whole cell lysate) A: Mouse brain 7. 5% SDS PAGE; antibody diluted at 1:1000. Western Blot: APPL Antibody [NBP2-15433] - Sample (30 ug of whole cell lysate) A: IMR32 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 26至33个工作日
¥3,655.56
详细
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: APPL Antibody [NBP2-15434] - Paraffin-embedded AZ521 xenograft, using antibody at 1:100 dilution. Western Blot: APPL Antibody [NBP2-15434] - Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 26至33个工作日
¥3,655.56
详细
Cow 山羊 非结合性 ELISA, WB 100 μg Log in to see 29至35个工作日
¥6,088.05
详细
山羊 非结合性 ELISA, WB Antibody (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 24至29个工作日
¥9,230.97
详细

通过反应活性、应用领域、克隆类型和共轭标记 APPL1 抗体

特性 应用范围 宿主 克隆类型 标记
Human ,
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Mouse (Murine)
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Rat (Rattus)
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引用最多的anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 抗体

  1. Mouse (Murine) Monoclonal APPL1 Primary Antibody for ICC, IF - ABIN1042584 : Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. in Oncogene 1999 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal APPL1 Primary Antibody for ELISA, WB - ABIN252906 : Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. in Nature cell biology 2006 (PubMed)

更多抗Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1的相互作用对抗体

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 positively mediated leptin (显示 LEP 抗体) signaling.

  2. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  3. Results indicate that persistent rab5 (显示 RAB5A 抗体) overactivation through beta-cleaved carboxy-terminal fragment of APP (显示 APP 抗体)-APPL1 interactions constitutes a novel APP (显示 APP 抗体)-dependent pathogenic pathway in Alzheimer's disease

  4. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  5. Low expression of APPL1 is associated with metastasis in prostate cancer.

  6. APPL1 endosomes represent a distinct population of Rab5 (显示 RAB5A 抗体)-positive sorting endosomes.

  7. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (显示 TSC2 抗体)

  8. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  9. A role for APPL1 in TLR3 (显示 TLR3 抗体)/4-dependent TBK1 (显示 TBK1 抗体) and IKKepsilon (显示 IKBKE 抗体) activation in macrophages.

  10. ATM (显示 ATM 抗体) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (显示 TLR4 抗体)-induced signaling, transcription, and cytokine secretion.

  2. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (显示 HGF 抗体)-induced Akt (显示 AKT1 抗体) activation, migration, and invasion.

  3. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (显示 PRKAA1 抗体) signaling.

  4. A role for APPL1 in TLR3 (显示 TLR3 抗体)/4-dependent TBK1 (显示 TBK1 抗体) and IKKepsilon (显示 IKBKE 抗体) activation in macrophages.

  5. APPL1 sensitizes insulin (显示 INS 抗体) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (显示 INS 抗体) signaling and crosstalk between the insulin (显示 INS 抗体) and adiponectin (显示 ADIPOQ 抗体) pathways.

  6. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  7. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (显示 INS 抗体) sensitivity.

  8. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (显示 INS 抗体) resistance and improves adipoR1 (显示 ADIPOR1 抗体)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  9. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (显示 AKT1 抗体) cascade in neurons.

  10. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (显示 INS 抗体) resistance to beta-cell dysfunction in type 2 diabetes.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) 抗原简介

蛋白简介

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) 抗体
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) 抗体
  • 2900057D21Rik 抗体
  • 7330406P05Rik 抗体
  • AI585782 抗体
  • APPL 抗体
  • AW209077 抗体
  • BB022931 抗体
  • C88264 抗体
  • DIP13 抗体
  • DIP13alpha 抗体
  • RGD1309388 抗体

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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