ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白 (ABCB1B)

The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上,我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 抗体 (30)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
ABCB1B 5243 P08183
ABCB1B 18669 P06795
大鼠 ABCB1B ABCB1B 24646  

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ABCB1B 蛋白 by Origin and Source

Origin 在表达 标记
Human

Mouse (Murine) ,
,

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Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. SMS (显示 SMS 蛋白) regulates the expression and function of drug transporters P-gp (显示 ABCB4 蛋白) and MRP2 (显示 ABCC2 蛋白).

  2. BZML is a novel colchicine binding site inhibitor and overcomes multi-drug resistance in A549/Taxol cells by inhibiting P-gp (显示 ABCB4 蛋白) function and inducing mitotic catastrophe.

  3. We have noted that the implication of C3435T variant on the risk of breast cancer was ethnicity-dependent. However, there is no evidence that ABCB1 (显示 ABCB1 蛋白) C3435T polymorphism could play a role in susceptibility to breast cancer in Morocco.

  4. no significant clinical relevance between Pgp expression and osteosarcoma survival

  5. Meta-analysis found no evidence for ABCB1 (显示 ABCB1 蛋白) C3435T and C1236T polymorphisms as risk factors for pediatric Acute Lymphoblastic Leukemia.

  6. ABCB1 (显示 ABCB1 蛋白) gene polymorphisms in association with others risk factors contribute to anti-TB drug resistance, mainly ethambutol.

  7. For the first time, we demonstrated that MDR1 rs1128503 polymorphisms were associated with systemic lupus erythematosus susceptibility in Chinese Guangxi population.

  8. multiple pathways, including MMP9 (显示 MMP9 蛋白) cleavage and ubiquitinylation, mediated P-gp (显示 ABCB4 蛋白) downmodulation.

  9. We also determined the effect of Pygo2 on the sensitivity of breast tumors resistant to doxorubicin in a mouse model. Finally, RNA samples from 64 paired patient tumors (before and after chemotherapy) highly and significantly overexpressed Pygo2 and/or MDR1 after treatment, thus underlining a pivotal role for the Pygo2-mediated Wnt/b-catenin pathway in the clinical chemoresistance of breast cancer.

  10. We did not find any relationship between the methylation levels of the ABCB1 (显示 ABCB1 蛋白) promoter and clopidogrel resistance (CR). In conclusions, our study indicated that ABCB1 (显示 ABCB1 蛋白) polymorphisms might be useful in further evaluating the pathogenesis of CR.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. Loss of ABCB1 (显示 ABCB1 蛋白) expression is associated with neonatal hyperbilirubinemia.

  2. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  3. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  4. Chrysosplenetin inhibited P-gp (显示 ABCB4 蛋白) activity and reverse the up-regulated P-gp (显示 ABCB4 蛋白) and MDR1 (显示 ABCB4 蛋白) levels induced by artemisinin.

  5. Tamsulosin and tolterodine with P-gp (显示 ABCB4 蛋白) gene expression and activity in an enantiomer-specific way.

  6. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  7. Data show that human transgenic mutant huntingtin (显示 HTT 蛋白) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (显示 ABCB4 蛋白)) which suggests that MDR1 (显示 ABCB4 蛋白) might be a potential therapeutic target for Huntington's disease.

  8. In vitro and in vivo downregulation of the ATP binding cassette transporter (显示 ABCC3 蛋白) B1 by the HMG-CoA reductase (显示 HMGCR 蛋白) inhibitor simvastatin

  9. Efficient chemoprotection of CDD (显示 CDA 蛋白) and MDR1 (显示 ABCB4 蛋白) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (显示 FOXC1 蛋白)-C and anthracycline application

  10. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (显示 ABCB1 蛋白)-1Delta mutant mice following exposure to various P-gp (显示 ABCB4 蛋白) substrates.

蛋白简介ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)

蛋白简介

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1B

  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • ABC20 蛋白
  • Abcb1 蛋白
  • CD243 蛋白
  • CLCS 蛋白
  • GP170 蛋白
  • mdr 蛋白
  • Mdr1 蛋白
  • Mdr1b 蛋白
  • P-GP 蛋白
  • Pgy-1 蛋白
  • Pgy1 蛋白

Protein level used designations for ABCB1B

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1

GENE ID SPECIES
5243 Homo sapiens
18669 Mus musculus
24646 Rattus norvegicus
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