anti-ATP Citrate Lyase (ACLY) 抗体

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. 再加上,我们可以发ACLY 试剂盒 (22)ACLY 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ACLY 47 P53396
ACLY 104112 Q91V92
ACLY 24159 P16638

antibodies-online.cn销售最多的anti-ACLY 抗体

Showing 10 out of 125 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB <b>WB Suggested Anti-ACLY Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>ACHN cell lysate WB Suggested Anti-ACLY <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: ACHN cell lysate <br /> ACLY is strongly supported by BioGPS gene expression data to be expressed in Human ACHN cells 100 μL Log in to see 5至7个工作日
¥20,898.73
详细
Cow 非结合性 WB <b>WB Suggested Anti-ACLY Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>ACHN cell lysate WB Suggested Anti-ACLY <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: ACHN cell lysate <br /> ACLY is strongly supported by BioGPS gene expression data to be expressed in Human ACHN cells 100 μL Log in to see 5至7个工作日
¥20,898.73
详细
小鼠 非结合性 ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HeLa cells using ACLY mouse mAb (green) and negative control (purple) . 0.1 mg Log in to see 24至29个工作日
¥10,808.99
详细
非结合性 IHC (p), WB   100 μg Log in to see 26至32个工作日
¥2,919.96
详细
非结合性 IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with Calyculin 50nM 30', using ATP-Citrate Lyase (Phospho-Ser454) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using ATP-Citrate Lyase (Phospho-Ser454) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 24至29个工作日
¥3,026.87
详细
非结合性 ELISA, WB Western blot analysis of extracts from COS7 cells, treated with Calyculin 50nM 30', using ATP-Citrate Lyase (Ab-454) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 24至29个工作日
¥3,026.87
详细
非结合性 ELISA, IF, WB Western Blot (WB) analysis of specific cells using ATP-citrate synthase Polyclonal Antibody. 100 μL Log in to see 34至38个工作日
¥4,371.67
详细
小鼠 非结合性 IF, IHC (p), WB Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE) 100 μL Log in to see 29至35个工作日
¥5,950.75
详细
小鼠 非结合性 FACS, ICC, WB   100 μL Log in to see 6至8个工作日
¥1,633.54
详细
非结合性 ICC, IF, WB 0.1 mL Log in to see 25至31个工作日
¥3,655.56
详细

通过反应活性、应用领域、克隆类型和共轭标记 ACLY 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-ACLY 抗体

  1. Human Monoclonal ACLY Primary Antibody for ICC, FACS - ABIN1098143 : Chu, Lin, Hendel, Kulpa, Brownsey, Johnson: ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 Pubmed References

  2. Cow (Bovine) Polyclonal ACLY Primary Antibody for IHC, WB - ABIN2775558 : Infantino, Iacobazzi, Palmieri, Menga: ATP-citrate lyase is essential for macrophage inflammatory response. in Biochemical and biophysical research communications 2013 (PubMed)

  3. Cow (Bovine) Polyclonal ACLY Primary Antibody for WB - ABIN2773810 : Convertini, Menga, Andria, Scala, Santarsiero, Castiglione Morelli, Iacobazzi, Infantino: The contribution of the citrate pathway to oxidative stress in Down syndrome. in Immunology 2016 (PubMed)

更多抗ACLY的相互作用对抗体

Human ATP Citrate Lyase (ACLY) interaction partners

  1. ACLY facilitates histone acetylation at double-strand break (DSB) sites, impairing 53BP1 localization and enabling BRCA1 recruitment and DNA repair by homologous recombination. ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment.

  2. The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen.

  3. CUL3 (显示 CUL3 抗体) interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY in cells

  4. we found that depletion of ATP citrate lyase suppressed tumor growth, which suggests that ATP citrate lyase-related inhibitors might be potential therapeutic approaches for breast cancer.

  5. Results show that ACLY is a key phosphoprotein effector of IL-2 (显示 IL2 抗体)-mediated T-cell responses. ACLY becomes phosphorylated on serine 455 in T lymphocytes upon IL-2 (显示 IL2 抗体)-driven activation of AKT (显示 AKT1 抗体), and depletion or inactivation of ACLY compromises IL-2 (显示 IL2 抗体)-promoted T-cell growth.

  6. ACLY was also required for LMW-E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo In clinical specimens of breast cancer, the absence of LMW-E and low expression of adipophilin (PLIN2 (显示 PLIN2 抗体)), a marker of lipid droplet formation, associated with favorable prognosis

  7. ACC1 (显示 ACACA 抗体) and ACLY regulate the levels of ETV4 (显示 ETV4 抗体) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1 (显示 ACACA 抗体)/ACLY-alpha-ketoglutarate-ETV4 (显示 ETV4 抗体) axis is a novel means by which metabolic states regulate transcriptional output

  8. ACL activity is associated with increased ATP. Activation of this IGF1 (显示 IGF1 抗体)/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.

  9. These results suggest that the combined expression of GLUT1 (显示 SLC2A1 抗体) and ACLY could be a more valuable prognostic factor than their individual expression in node-negative patients with NSCLC.

  10. Polymorphisms of ATP citrate lyase gene is associated with recurrence in colorectal cancer.

Mouse (Murine) ATP Citrate Lyase (ACLY) interaction partners

  1. ACL (显示 APOC4 抗体) plays a critical role in epigenetic regulation of diabetic renal fibrosis.

  2. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr (显示 LDLR 抗体) knockout mouse model of metabolic dysregulation.

  3. IL-4 (显示 IL4 抗体) signaling co-opts the Akt (显示 AKT1 抗体)-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA (显示 LPCAT1 抗体) synthesis, leading to increased histone acetylation and macrophage gene induction.

  4. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS (显示 TLR4 抗体) signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation

  5. Results suggest a role for DNA methyltransferase 1 (DNMT1 (显示 DNMT1 抗体)) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR (显示 MLXIP 抗体)-148a-dependent mechanism for regulating DNMT1 (显示 DNMT1 抗体) during adipogenesis.

  6. Differences between human and rodent pancreatic islets: low pyruvate carboxylase (显示 PC 抗体), atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

  7. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL (显示 APOC4 抗体) in lipid metabolism.

  8. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.

  9. crucial role of hepatic ATP-citrate lyase in lipid and glucose metabolism

  10. findings suggest that ATP-citrate lyase activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene expression

Pig (Porcine) ATP Citrate Lyase (ACLY) interaction partners

  1. The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2 (显示 TFAP2A 抗体).

Cow (Bovine) ATP Citrate Lyase (ACLY) interaction partners

  1. we identified three non-synonymous mutations in ACLY exons in five beef cattle populations. Single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth and body height, and with body slanting length. SNP g.40427T>C is significantly associated with an increase in chest girth. ACLY gene are associated with growth traits in beef cattle in northwest China

ACLY 抗原简介

蛋白简介

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with anti-ATP Citrate Lyase (ACLY) 抗体

  • ATP citrate lyase (ACLY) 抗体
  • ATP citrate lyase (acly) 抗体
  • ATP citrate lyase (ATPCL) 抗体
  • ATP-citrate synthase (AaeL_AAEL004297) 抗体
  • citrate synthase, mitochondrial (CpipJ_CPIJ010291) 抗体
  • ATP-citrate synthase (Bm1_26245) 抗体
  • atp-citrate synthase (ACL) 抗体
  • ATP citrate lyase (Acly) 抗体
  • ATP citrate lyase a (aclya) 抗体
  • A730098H14Rik 抗体
  • ACL 抗体
  • acly 抗体
  • anon-WO0140519.179 抗体
  • ATPCL 抗体
  • AW538652 抗体
  • BcDNA:LD21334 抗体
  • cb722 抗体
  • CG8322 抗体
  • Clatp 抗体
  • dATPCL 抗体
  • DDBDRAFT_0205389 抗体
  • DDBDRAFT_0235360 抗体
  • DDB_0205389 抗体
  • DDB_0235360 抗体
  • DmATPCL 抗体
  • Dmel\\CG8322 抗体
  • l(2)01466 抗体
  • l(2)k09217 抗体
  • n(2)k09217 抗体
  • zgc:92008 抗体

Protein level used designations for anti-ATP Citrate Lyase (ACLY) 抗体

ATP citrate lyase , ATP citrate synthase , ATP-citrate synthase-like , ATP-citrate lyase , ATPCL-PD , ATPCL-PE , ATPCL-PF , CG8322-PD , CG8322-PE , CG8322-PF , ATP-citrate synthase , citrate synthase, mitochondrial , atp-citrate synthase , ATP-citrate (pro-S-)-lyase , citrate cleavage enzyme

GENE ID SPECIES
100053195 Equus caballus
454672 Pan troglodytes
495086 Xenopus laevis
587157 Strongylocentrotus purpuratus
708501 Macaca mulatta
8621508 Dictyostelium discoideum AX4
100405725 Callithrix jacchus
100422779 Felis catus
100439535 Pongo abelii
100467494 Ailuropoda melanoleuca
36760 Drosophila melanogaster
5564509 Aedes aegypti
6042632 Culex quinquefasciatus
6100149 Brugia malayi
7201075 Phaeodactylum tricornutum CCAP 1055/1
47 Homo sapiens
104112 Mus musculus
24159 Rattus norvegicus
100125957 Sus scrofa
511135 Bos taurus
395373 Gallus gallus
607852 Canis lupus familiaris
654404 Ovis aries
436922 Danio rerio
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