anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) 抗体

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. 再加上,我们可以发APEX2 蛋白 (3)APEX2 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
APEX2 27301 Q9UBZ4
APEX2 289662  
APEX2 77622 Q68G58

antibodies-online.cn销售最多的anti-APEX2 抗体

Showing 10 out of 59 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 FACS, IF, IHC (p), WB Western blot analysis of APEX2 Antibody (Center) (ABIN652924) in MCF-7 cell line lysates (35 µg/lane). APEX2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with APEX2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 5至8个工作日
¥2,325.14
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非结合性 WB Western Blot: APEX2 Antibody [ABIN42810615] - Western blot analysis of APEXL2 in HeLa cell lysates using ABIN42810615 at a dilution of 1:500. 0.2 mL Log in to see 25至31个工作日
¥2,594.28
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非结合性 IHC (p), WB 50 μL Log in to see 29至35个工作日
¥5,095.23
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非结合性 IHC (p), WB Anti- APEX2 antibody, Western blotting All lanes: Anti APEX2  at 0.5ug/ml WB: SMMC Whole Cell Lysate at 40ug Predicted bind size: 57KD Observed bind size: 57KD Anti- APEX2 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 26至32个工作日
¥2,560.58
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非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-APEX2 Polyclonal Antibody, Unconjugated (ABIN718481) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 5至7个工作日
¥2,610.23
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Cow 非结合性 IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 29至35个工作日
¥4,324.07
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Alexa Fluor 594 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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大鼠 非结合性 WB   100 μg Log in to see 26至32个工作日
¥2,919.96
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Alexa Fluor 350 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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Alexa Fluor 488 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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通过反应活性、应用领域、克隆类型和共轭标记 APEX2 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-APEX2 抗体

  1. Human Polyclonal APEX2 Primary Antibody for FACS, IF - ABIN652924 : Hadi, Ginalski, Nguyen, Wilson: Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. in Journal of molecular biology 2002 (PubMed)

  2. Human Polyclonal APEX2 Primary Antibody for WB - ABIN4281061 : Karkhanis, Wang, Tae, Hu, Imbalzano, Sif: Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1. in The Journal of biological chemistry 2012 (PubMed)

更多抗APEX2的相互作用对抗体

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. APE2 associates with Chk1 (显示 CHEK1 抗体); a serine residue (S86) in the Chk1 (显示 CHEK1 抗体)-binding motif of APE2 is essential for Chk1 (显示 CHEK1 抗体) phosphorylation, indicating a Claspin (显示 CLSPN 抗体)-like but distinct role for APE2 in ATR (显示 ATR 抗体)-Chk1 (显示 CHEK1 抗体) signaling.

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. Determinants in nuclease (显示 DCLRE1C 抗体) specificity of Ape1 (显示 APEX1 抗体) and Ape2, human homologues of Escherichia coli exonuclease (显示 EXO1 抗体) III

  2. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  3. Ape2 may be involved in repair of oxidative DNA damage and PCNA (显示 PCNA 抗体)-dependent repair synthesis.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE (显示 RPLP0 抗体)) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (显示 AICDA 抗体) (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 (显示 APEX1 抗体) and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte (显示 AKAP17A 抗体) transition, due to a p53 (显示 TP53 抗体)-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1 (显示 APEX1 抗体).

  5. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  6. Both APE1 (显示 APEX1 抗体) and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  7. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  8. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 抗原简介

蛋白简介

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with APEX2

  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) 抗体
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) 抗体
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 (Apex2l1) 抗体
  • apurinic/apyrimidinic endonuclease 2 (Apex2) 抗体
  • APE2 抗体
  • APEXL2 抗体
  • C430040P13Rik 抗体
  • XTH2 抗体
  • zgc:55889 抗体

Protein level used designations for APEX2

DNA-(apurinic or apyrimidinic site) lyase 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like , AP endonuclease 2 , AP endonuclease XTH2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2

GENE ID SPECIES
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
27301 Homo sapiens
491499 Canis lupus familiaris
511790 Bos taurus
289662 Rattus norvegicus
77622 Mus musculus
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