ZAP70 产品
(zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))
Categories
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured ZAP70 Categories
ZAP70 抗体
High quality antibodies with extensive validation data.
ZAP70 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ZAP70 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ZAP70 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, ICC
Validations
- (1)
- (6)
Cat. No.
ABIN125756
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (8)
Cat. No.
ABIN6255884
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA, FACS, IF, StM, Coat
Validations
- (5)
Cat. No.
ABIN6940913
Quantity
100 μg
Datasheet
Datasheet
Recommended ZAP70 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971215
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4886351
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380734
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended ZAP70 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
Cat. No.
ABIN1325570
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
Cat. No.
ABIN5570597
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325572
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ZAP70 Products
: "Fibulin-3 may improve vascular health through inhibition of MMP-2/9 and oxidative stress in spontaneously hypertensive rats." in: Molecular medicine reports, Vol. 13, Issue 5, pp. 3805-12, (2017) (PubMed).: "Hypertensive vascular remodeling was inhibited by Xuezhikang through the regulation of Fibulin-3 and MMPs in spontaneously hypertensive rats." in: International journal of clinical and experimental medicine, Vol. 8, Issue 2, pp. 2118-27, (2015) (PubMed).
: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).
: "ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells." in: Blood, Vol. 109, Issue 5, pp. 2032-9, (2007) (PubMed).
: "CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization." in: European journal of immunology, Vol. 38, Issue 1, pp. 40-7, (2007) (PubMed).
: "T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 12, pp. 8123-32, (2005) (PubMed).
: "Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms." in: The Journal of pathology, Vol. 205, Issue 4, pp. 507-13, (2005) (PubMed).
: "[Everything you ever wanted to know about ZAP-70]." in: Médecine sciences : M/S, Vol. 21, Issue 2, pp. 150-5, (2005) (PubMed).
: "In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer." in: The Journal of clinical investigation, Vol. 115, Issue 8, pp. 2287-95, (2005) (PubMed).
: "Evidence for the involvement of tyrosine kinase ZAP 70 in nuclear retinoid receptor-dependent transactivation in T lymphocytes." in: The Journal of biological chemistry, Vol. 280, Issue 40, pp. 34152-8, (2005) (PubMed).
Synonyms and alternative names related to ZAP70
zeta chain of T-cell receptor associated protein kinase 70 (ZAP70), putative tyrosine-protein kinase zap-70 (Smp_149470), zeta-chain (TCR) associated protein kinase (Zap70), zeta chain of T cell receptor associated protein kinase 70 (Zap70), zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), zeta chain of T cell receptor associated protein kinase 70kDa L homeolog (zap70.L), zeta chain of T cell receptor associated protein kinase 70kDa (zap70), zeta chain of T cell receptor associated protein kinase 70 (ZAP70), tyrosine-protein kinase ZAP-70 (LOC707555), tyrosine-protein kinase ZAP-70 (ZAP70), tyrosine-protein kinase ZAP-70 (LOC100342021), tyrosine-protein kinase ZAP-70 (LOC100390922), tyrosine-protein kinase ZAP-70 (LOC100542877), zeta-chain (TCR) associated protein kinase 70kDa (Zap70), zeta-chain (TCR) associated protein kinase (zap70), 70kDa, AI327364, MGC80670, MGC88962, mrtle, mur, SRK, Srk, STCD, STD, TZK, ZAP-70, zap70, ZAP70, zgc:110383Protein level used designations for ZAP70
- 70 kDa zeta-associated protein
- 70 kDa zeta-chain associated protein
- syk-related tyrosine kinase
- tyrosine-protein kinase ZAP-70
- zeta-chain associated protein kinase, 70kD
- tyrosine-protein kinase zap-70
- syk-related protein tyrosine kinase
- zeta-chain (TCR) associated protein kinase 70kDa
- zeta-chain associated protein kinase 70kDa
- tyrosine-protein kinase ZAP-70-like
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