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抗Human IGFBP5 抗体:
抗Mouse (Murine) IGFBP5 抗体:
抗Rat (Rattus) IGFBP5 抗体:
Data suggest that IGFBP5 nuclear import is mediated by KPNA5 (显示 KPNA5 抗体)/KPNB1 (显示 KPNB1 抗体) complex; nuclear localization sequence of IGFBP5 is critical domain in this nuclear translocation. (IGFBP5 = insulin-like growth factor binding protein-5; KPNA5 (显示 KPNA5 抗体) = karyopherin subunit alpha-5 (显示 KPNA5 抗体); KPNB1 (显示 KPNB1 抗体) = karyopherin subunit beta-1/importin-beta (显示 KPNB1 抗体))
These results suggest that the C-terminus of IGFBP-5 exerts anti-cancer activity by inhibiting angiogenesis via regulation of the Akt (显示 AKT1 抗体)/ERK (显示 EPHB2 抗体) and NF-kB-VEGF (显示 VEGFA 抗体)/MMP-9 (显示 MMP9 抗体) signaling pathway.
AMP (显示 APRT 抗体)-IBP5 markedly enhanced keratinocyte migration and proliferation. AMP (显示 APRT 抗体)-IBP5-induced keratinocyte activation was mediated by Mrg (显示 FABP7 抗体) X1-X4 receptors with MAPK (显示 MAPK1 抗体) and NF-kappaB (显示 NFKB1 抗体) pathways.
Factor Xa (显示 F10 抗体) induced endothelial cell senescence through IGFBP-5.
Co-ordinated and reciprocal alteration in IGFBP-2 (显示 IGFBP2 抗体) and -5 expression may play a role in the acquisition of endocrine resistance in breast cancer.
The findings suggest that miR (显示 MLXIP 抗体)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 (显示 ADAMTS5 抗体) and IGFBP5.
MiR (显示 MLXIP 抗体)-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR (显示 FRAP1 抗体)/STAT3 (显示 STAT3 抗体) signaling.
dysregulation of DNMT3A (显示 DNMT3A 抗体) and IGFBP5 is relevant to preeclampsia. Thus, we propose that DNMT3A (显示 DNMT3A 抗体) and IGFBP5 can serve as potential markers and targets for the clinical diagnosis and therapy of preeclampsia.
IGFBP5 promoter and exon-I methylation did not have any differences between tumor and adjacent tissues so that IGFBP5 methylation did not change IGFBP5 gene regulation in breast cancer.
IGFBP5 promoted osteogenic differentiation potentials of periodontal ligament stem cells and Wharton's jelly umbilical cord stem cells via the JNK (显示 MAPK8 抗体) and MEK (显示 MAP2K1 抗体)/Erk (显示 EPHB2 抗体) signalling pathways.
Data demonstrate that dysregulation of miR (显示 MLXIP 抗体)-143-3p:Igfbp5 interactions in satellite cells with age may be responsible for age-related changes in satellite cell function.
proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R (显示 IGF1R 抗体) inhibitors
Results from mouse models suggest that inhibiting the up-regulation of IGFBP5 expression in peripheral nerves might prevent or slow down diabetic neuropathy disease progression
IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5 (显示 DOK5 抗体). IGFBP-5 and DOK5 (显示 DOK5 抗体) are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
Igfbp2 (显示 IGFBP2 抗体)-5 are expressed in distinct and complementary patterns during cochlear development.
indicate that Igf1 (显示 IGF1 抗体) was highly expressed in the mesenchyme, Igf2 and Igf1r (显示 IGF1R 抗体) were expressed in both the midline epithelium and surrounding mesenchyme, and Igfbp5 was highly expressed in the epithelium.
we have identified a single polymorphic locus that affects skin and lung tumorigenesis and identify Igfbp5 and Igfbp2 (显示 IGFBP2 抗体) as candidate modifier genes of lung tumorigenesis.
investigated the effect of IGFBP5 induction on the progression of liver fibrosis caused by chronic cholangiopathy; expression of IGFBP5 in the Abcb4 (显示 ABCB4 抗体)-/- mice reduces inflammation, oxidative stress, ECM (显示 MMRN1 抗体) deposition and hepatocyte proliferation, thereby reducing liver fibrosis
c-Src (显示 SRC 抗体) and IL-6 (显示 IL6 抗体) inhibit osteoblast differentiation and integrate IGFBP5 signalling
Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.
The present study revealed SNPs in exon 1 of IGFBP-5 gene (显示 GPD1 抗体) in the Tibet Mini-pig, possibly providing more understanding of the mechanism of miniaturization
IGFBP-5 gene (显示 GPD1 抗体) is associated with the variation in meat quality, especially in pH value together with other QTLs on chromosome 15.
Endogenous IGFBP-5 or transiently expressed IGFBP-5-EGFP is localized in the nuclei of VSMCs. It possesses transcription-regulatory activity that is IGF independent.
IGFBP5, an important component of IGF signaling pathway, contributes greatly to bovine muscle cell development. A mechanism that miR (显示 MYLIP 抗体)-143 can regulate the proliferation and differentiation of bovine MSCs through changing expression of IGFBP5 was elucidated by our study.
This study suggested that that higher level IGFBP-5 expression may have functional significance in lactation persistency.
follicular dominance was associated with low or decreased follicular fluid concentrations of IGFBP-4 (显示 IGFBP4 抗体) and -5
GH reduces mRNA and protein expression of IGFBP-5 in bovine mammary epithelial cells, but it does not affect the expression of IGFBP-3 (显示 IGFBP3 抗体)
The transgene in the cell clones was examined by polymerase chain reaction to verify that exogenous DNA (pKAP6-1 and IGFBP-5) had integrated stably into GFb cells
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
, IGF-binding protein 5
, insulin-like growth factor-binding protein 5
, insulin-like growth factor binding protein-5
, insulin-like growth factor binding protein 5
, insulin-like growth factor binding protein 5a
, insulin-like growth factor binding protein 5b