The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].
Zhu, Gilbert, Liang, Kang, Li, Tarantino, Jilma: "Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200." in: Journal of thrombosis and haemostasis : JTH, Vol. 18, Issue 7, pp. 1695-1704, (2020) (PubMed).
Zhu, Gilbert, Hatala, Harvey, Liang, Gao, Kang, Jilma: "The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer." in: Journal of thrombosis and haemostasis : JTH, Vol. 18, Issue 5, pp. 1113-1123, (2020) (PubMed).
Qi, Chen, Liang, Xu, Gu, Wu, Fan, Ren, Liu, Zhang, Li, Liu, Liang: "Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction." in: Journal of hematology & oncology, Vol. 11, Issue 1, pp. 117, (2020) (PubMed).
Aliases for VWF 蛋白
von Willebrand factor (VWF) 蛋白 von Willebrand factor (vwf) 蛋白 von Willebrand factor (Vwf) 蛋白 Von Willebrand factor (Vwf) 蛋白 6820430P06Rik 蛋白 AI551257 蛋白 B130011O06Rik 蛋白 C630030D09 蛋白 F8VWF 蛋白 si:ch1073-474e24.1 蛋白 VWD 蛋白 VWF 蛋白