VRK1 抗体
(Vaccinia Related Kinase 1 (VRK1))
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| VRK1 抗体 (Center) | 人, 小鼠 | 兔 Polyclonal |
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| VRK1 抗体 | 人 | 小鼠 Monoclonal |
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| VRK1 抗体 | 人, 小鼠 | 兔 Polyclonal |
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Primary Antibody
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 366-396, Center
Latest Publications for our VRK1 抗体
: "VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle." in: Scientific reports, Vol. 5, pp. 10543, (2015) (PubMed).
: "Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes." in: Molecular biology of the cell, Vol. 25, Issue 6, pp. 891-903, (2014) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response." in: Oncotarget, Vol. 5, Issue 7, pp. 1770-8, (2014) (PubMed).
: "Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo." in: Oncogenesis, Vol. 2, pp. e48, (2013) (PubMed).
: "Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas." in: Nature communications, Vol. 4, pp. 1701, (2013) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage." in: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23757-68, (2012) (PubMed).
: "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines." in: The FEBS journal, Vol. 273, Issue 11, pp. 2487-504, (2006) (PubMed).
: "Characterization of three paralogous members of the Mammalian vaccinia related kinase family." in: The Journal of biological chemistry, Vol. 279, Issue 9, pp. 7934-46, (2004) (PubMed).
: "Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1." in: Archives of biochemistry and biophysics, Vol. 399, Issue 1, pp. 1-5, (2002) (PubMed).
: "The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein." in: Oncogene, Vol. 19, Issue 32, pp. 3656-64, (2000) (PubMed).
: "Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes." in: Molecular biology of the cell, Vol. 25, Issue 6, pp. 891-903, (2014) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response." in: Oncotarget, Vol. 5, Issue 7, pp. 1770-8, (2014) (PubMed).
: "Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo." in: Oncogenesis, Vol. 2, pp. e48, (2013) (PubMed).
: "Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas." in: Nature communications, Vol. 4, pp. 1701, (2013) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage." in: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23757-68, (2012) (PubMed).
: "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines." in: The FEBS journal, Vol. 273, Issue 11, pp. 2487-504, (2006) (PubMed).
: "Characterization of three paralogous members of the Mammalian vaccinia related kinase family." in: The Journal of biological chemistry, Vol. 279, Issue 9, pp. 7934-46, (2004) (PubMed).
: "Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1." in: Archives of biochemistry and biophysics, Vol. 399, Issue 1, pp. 1-5, (2002) (PubMed).
: "The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein." in: Oncogene, Vol. 19, Issue 32, pp. 3656-64, (2000) (PubMed).
Aliases for VRK1 抗体
vaccinia related kinase 1 L homeolog (vrk1.L) 抗体vaccinia related kinase 1 (vrk1) 抗体
vaccinia related kinase 1 (VRK1) 抗体
Serine/threonine-protein kinase VRK1 (vrk-1) 抗体
vaccinia related kinase 1 (Vrk1) 抗体
51PK 抗体
MGC64390 抗体
MGC75762 抗体
PCH1 抗体
PCH1A 抗体
vrk1 抗体
VRK1 抗体
wu:fe16f06 抗体
zgc:56266 抗体
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