VRK1 产品
(Vaccinia Related Kinase 1 (VRK1))
Categories
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].
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Featured VRK1 Categories
VRK1 抗体
High quality antibodies with extensive validation data.
VRK1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
VRK1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended VRK1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IP, IF, RNAi
Validations
- (6)
Cat. No.
ABIN521352
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP, IF
Validations
- (11)
Cat. No.
ABIN2452161
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7169217
Quantity
100 μL
Datasheet
Datasheet
Recommended VRK1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960427
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1157429
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1157427
Quantity
96 tests
Datasheet
Datasheet
Recommended VRK1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7556015
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325109
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509194
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our VRK1 Products
: "VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle." in: Scientific reports, Vol. 5, pp. 10543, (2015) (PubMed).: "Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes." in: Molecular biology of the cell, Vol. 25, Issue 6, pp. 891-903, (2014) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response." in: Oncotarget, Vol. 5, Issue 7, pp. 1770-8, (2014) (PubMed).
: "Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo." in: Oncogenesis, Vol. 2, pp. e48, (2013) (PubMed).
: "Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas." in: Nature communications, Vol. 4, pp. 1701, (2013) (PubMed).
: "Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage." in: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23757-68, (2012) (PubMed).
: "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines." in: The FEBS journal, Vol. 273, Issue 11, pp. 2487-504, (2006) (PubMed).
: "Characterization of three paralogous members of the Mammalian vaccinia related kinase family." in: The Journal of biological chemistry, Vol. 279, Issue 9, pp. 7934-46, (2004) (PubMed).
: "Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1." in: Archives of biochemistry and biophysics, Vol. 399, Issue 1, pp. 1-5, (2002) (PubMed).
: "The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein." in: Oncogene, Vol. 19, Issue 32, pp. 3656-64, (2000) (PubMed).
Synonyms and alternative names related to VRK1
vaccinia related kinase 1 L homeolog (vrk1.L), vaccinia related kinase 1 (vrk1), vaccinia related kinase 1 (VRK1), Serine/threonine-protein kinase VRK1 (vrk-1), vaccinia related kinase 1 (Vrk1), 51PK, MGC64390, MGC75762, PCH1, PCH1A, vrk1, VRK1, wu:fe16f06, zgc:56266Protein level used designations for VRK1
- vaccinia related kinase 1
- serine/threonine-protein kinase VRK1
- serine/threonine-protein kinase VRK1-like
- vaccinia virus B1R-related kinase 1
- vaccinia-related kinase 1
- serine/threonine-protein kinase 51PK
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