Vpx Protein 抗体
(Vpx Protein (VPX))
Plays a role in nuclear translocation of the viral pre- integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity). {ECO:0000250}.
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Vpx Protein 抗体
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Recommended Vpx Protein 抗体
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Datasheet
Reactivity
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Quantity
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Cat. No.
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Quantity
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Datasheet
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Reactivity
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Cat. No.
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Quantity
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Datasheet
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Synonyms and alternative names related to Vpx Protein
vpx protein (vpx)Protein level used designations for Vpx Protein
- Viral protein X
- X ORF protein
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