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Human PGF Protein expressed in Escherichia coli (E. coli) - ABIN413725
Ding, Huang, Song, Gao, Yuan, Wang, Cai, Fu, Luo: NFAT1 mediates placental growth factor-induced myelomonocytic cell recruitment via the induction of TNF-alpha. in Journal of immunology (Baltimore, Md. : 1950) 2010
Rat (Rattus) PGF Protein expressed in Escherichia coli (E. coli) - ABIN2126310
Zhang, Zhao, Yuan, Wu, Jiang, Luo, Zhao: Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway. in International immunopharmacology 2016
The present study investigated the interplay of VEGF (显示 VEGFA 蛋白)-A165a isoform, the anti-angiogenic VEGF (显示 VEGFA 蛋白)-A165b, placental growth factor (PIGF) and their receptors, VEGFR1 (显示 FLT1 蛋白) and VEGFR2 (显示 KDR 蛋白), on junctional occupancy of VE-cadherin (显示 CDH5 蛋白) and macromolecular leakage in human endothelial monolayers and the perfused placental microvascular bed.
PIGF (显示 PIGF 蛋白) enhances TLR-signaling upstream of IKK (显示 CHUK 蛋白) and contributes to an exaggerated pathologic pro-inflammatory state in response to activation of maternal and fetal mononuclear phagocytes by specific TLR agonists
Lower PIGF (显示 PIGF 蛋白) and higher PAPP-A (显示 PAPPA 蛋白) and free beta-hCG (显示 CGA 蛋白) levels were found in the fetal circulation of near-term severe preeclamptic pregnancies
The early variations of PIGF (显示 PIGF 蛋白) and soluble fms-like tyrosine kinase-1 (显示 FLT1 蛋白) concentrations in newly pregnant obstetric antiphospholipid syndrome (oAPS) may help to detect patients at low risk of placenta-mediated complications (PMC).
There is a significant negative correlation between the concentration of sFLt-1 and PIGF (显示 PIGF 蛋白) in normal pregnancy.
knockdown of PIGF (显示 PIGF 蛋白) in spheroid body cells derived from two gastric cancer cell lines reduced in vitro tumorigenicity and stemness properties of spheroid body cells such as self-renewal ability, colony forming, migratory, and MMPs activities and decreased ability to differentiation and angiogenesis
Data showed that sFlt-1/PIGF (显示 PIGF 蛋白) ratio increases with volume overload and persistent hypoxia after surgery with CHD (显示 CHDH 蛋白).
Glioma cell-released PIGF (显示 PIGF 蛋白) can induce Bregs to suppress CD8 (显示 CD8A 蛋白)(+) T cell activities.
VEGF (显示 VEGFA 蛋白)/PIGF (显示 PIGF 蛋白) levels were higher in neonates exposed to pre-eclampsia, and there was a significant negative correlation between birth weight and VEGF (显示 VEGFA 蛋白)/PIGF (显示 PIGF 蛋白) levels.
In chronic kidney patients not yet on dialysis, higher serum level of PIGF (显示 PIGF 蛋白) are associated with increased mortality, but not cardiovascular events.
Data indicate that VEGF-B (显示 VEGFB 蛋白) is a high-affinity VEGFR-1 (显示 FLT1 蛋白) ligand that, unlike PIGF (显示 PIGF 蛋白), cannot efficiently induce signaling downstream of VEGFR-1 (显示 FLT1 蛋白).
the lack of PIGF (显示 PIGF 蛋白) may have contributed to the delayed angiogenic response and the prothrombotic phenotype observed in the PIGF (显示 PIGF 蛋白)(-/-)animals.
Overexpression of VEGF (显示 VEGFA 蛋白) but not PIGF (显示 PIGF 蛋白) exacerbated the lipopolysaccharide-mediated toxic effects, supporting a pathophysiological role for VEGF (显示 VEGFA 蛋白) in mediating the sepsis phenotype.
Findings indicate that placental growth factor (PlGF) plays an important role in liver fibrosis-associated angiogenesis and that blockage of PlGF could be an effective strategy for chronic liver disease.
Data demonstrate that PlGF is expressed in vivo and that its expression is restricted to the areas of the tumors where the highest levels of hypoxia occur. Also, hypoxia activates PlGF expression in cultured lymphatic endothelial cells.
Study provides mechanistic and clinical evidence that decreased PLGF levels in the placenta after in utero alcohol exposure are associated to brain angiogenesis defects. Measurement of PLGF levels at birth in the placenta or the fetal blood may serve as a predictive marker for subsequent neurodevelopmental outcomes of exposed fetuses.
PGF (显示 PTGFR 蛋白) deficiency is associated with impaired cerebral vascular development in mice.
PlGF inhibition attenuates PERK (显示 EIF2AK3 蛋白) activation, likely by tempering hypoxia in HCC (显示 FAM126A 蛋白) via vessel normalisation. The UPR is able to regulate PlGF expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR
Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13 (显示 IL13 蛋白).
Data indicate that placental growth factor (PlGF) is needed in the spleen to allow the activation of T cells and blood pressure raising.
Study reports polymorphisms in the bovine PGF gene significantly associated with the maternal effect on stillbirth and calving ease in animals under selection.
placenta growth factor expression is regulated by both VEGF (显示 VEGFA 蛋白) and hyperglycaemia via VEGFR-2 (显示 KDR 蛋白)
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.
placenta growth factor
, placental growth factor, vascular endothelial growth factor-related protein
, placenta growth factor-like