Vascular Endothelial Growth Factor A 蛋白
(Vascular Endothelial Growth Factor A (VEGFA))
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008].
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Rockland Original
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Latest Publications for our Vascular Endothelial Growth Factor A 蛋白
: "Fisetin inhibits vascular endothelial growth factor-induced angiogenesis in retinoblastoma cells." in: Oncology letters, Vol. 20, Issue 2, pp. 1239-1244, (2020) (PubMed).
: "Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition." in: Cell research, Vol. 29, Issue 11, pp. 895-910, (2020) (PubMed).
: "An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells." in: Scientific reports, Vol. 9, Issue 1, pp. 16954, (2019) (PubMed).
: "PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs." in: Nature communications, Vol. 8, Issue 1, pp. 672, (2018) (PubMed).
: "Directing and Potentiating Stem Cell-Mediated Angiogenesis and Tissue Repair by Cell Surface E-Selectin Coating." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154053, (2017) (PubMed).
: "Efficient Production of a Bioactive Bevacizumab Monoclonal Antibody Using the 2A Self-cleavage Peptide in Transgenic Rice Callus." in: Frontiers in plant science, Vol. 7, pp. 1156, (2016) (PubMed).
: "The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11947-54, (1991) (PubMed).
: "Vascular endothelial growth factor is a secreted angiogenic mitogen." in: Science (New York, N.Y.), Vol. 246, Issue 4935, pp. 1306-9, (1990) (PubMed).
: "Vascular permeability factor, an endothelial cell mitogen related to PDGF." in: Science (New York, N.Y.), Vol. 246, Issue 4935, pp. 1309-12, (1990) (PubMed).
: "Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition." in: Cell research, Vol. 29, Issue 11, pp. 895-910, (2020) (PubMed).
: "An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells." in: Scientific reports, Vol. 9, Issue 1, pp. 16954, (2019) (PubMed).
: "PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs." in: Nature communications, Vol. 8, Issue 1, pp. 672, (2018) (PubMed).
: "Directing and Potentiating Stem Cell-Mediated Angiogenesis and Tissue Repair by Cell Surface E-Selectin Coating." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154053, (2017) (PubMed).
: "Efficient Production of a Bioactive Bevacizumab Monoclonal Antibody Using the 2A Self-cleavage Peptide in Transgenic Rice Callus." in: Frontiers in plant science, Vol. 7, pp. 1156, (2016) (PubMed).
: "The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11947-54, (1991) (PubMed).
: "Vascular endothelial growth factor is a secreted angiogenic mitogen." in: Science (New York, N.Y.), Vol. 246, Issue 4935, pp. 1306-9, (1990) (PubMed).
: "Vascular permeability factor, an endothelial cell mitogen related to PDGF." in: Science (New York, N.Y.), Vol. 246, Issue 4935, pp. 1309-12, (1990) (PubMed).
Aliases for Vascular Endothelial Growth Factor A 蛋白
vascular endothelial growth factor A (VEGFA) 蛋白vascular endothelial growth factor A (Vegfa) 蛋白
vascular endothelial growth factor Aa (vegfaa) 蛋白
vascular endothelial growth factor A L homeolog (vegfa.L) 蛋白
vascular endothelial growth factor A (vegfa) 蛋白
vascular endothelial growth factor Ab (vegfab) 蛋白
eVEGF120 蛋白
eVEGF164 蛋白
MVCD1 蛋白
si:dkey-14d8.3 蛋白
vefg 蛋白
VEGF 蛋白
Vegf 蛋白
vegf 蛋白
VEGF-A 蛋白
vegf-a 蛋白
Vegf120 蛋白
Vegf164 蛋白
VEGF164 蛋白
Vegf188 蛋白
vegfa 蛋白
VPF 蛋白
Vpf 蛋白
vpf 蛋白
wu:fd42e02 蛋白
wu:fj82c06 蛋白
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