Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity).
Mosbech, Lukas, Bekker-Jensen, Mailand: "The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases." in: The Journal of biological chemistry, Vol. 288, Issue 23, pp. 16579-87, (2013) (PubMed).
Puente, Sánchez, Overall, López-Otín: "Human and mouse proteases: a comparative genomic approach." in: Nature reviews. Genetics, Vol. 4, Issue 7, pp. 544-58, (2003) (PubMed).
Aliases for USP3 抗体
ubiquitin specific peptidase 3 (usp3) 抗体 ubiquitin specific peptidase 3 (USP3) 抗体 ubiquitin specific peptidase 3 L homeolog (usp3.L) 抗体 ubiquitin specific peptidase 3 (Usp3) 抗体 AA409661 抗体 BC017156 抗体 fe50h06 抗体 SIH003 抗体 UBP 抗体 USP3 抗体 wu:fe50h06 抗体