(Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010].
Kiliç, Işik, Usta, Demirdaş: "Serum tumor necrosis factor-like weak inducer of apoptosis levels are elevated in schizophrenia." in: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), (2020) (PubMed).
Bilir, Engin, Can, Likhan, Demirtas, Kuzu, Bayraktaroglu: "Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer." in: Oncology letters, Vol. 9, Issue 6, pp. 2819-2824, (2015) (PubMed).