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抗Human GRHL2 抗体:
抗Mouse (Murine) GRHL2 抗体:
抗Rat (Rattus) GRHL2 抗体:
Human Polyclonal GRHL2 Primary Antibody for ICC, IF - ABIN4316153
Varma, Cao, Tagne, Lakshminarayanan, Li, Friedman, Morell, Warburton, Kotton, Ramirez: The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. in The Journal of biological chemistry 2012
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Human Polyclonal GRHL2 Primary Antibody for ELISA, WB - ABIN566411
Kang, Chen, Kim, Kang, Park: Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells. in Oncogene 2009
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Human Polyclonal GRHL2 Primary Antibody for IF, WB - ABIN529152
Dompe, Rivers, Li, Cordes, Schwickart, Punnoose, Amler, Seshagiri, Tang, Modrusan, Davis: A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2011
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GRHL2 gene may have a role in orbital innervations and the defect in this gene (deletion) may be related to the Congenital fibrosis of the extraocular muscles type 1 phenotype.
In this study, we demonstrated for the first time that GRHL2 has a functional role in the regulation of epithelial plasticity of PDAC cells.
data analysis and modeling results highlight the relationships among multiple crucial Epithelial-to-Mesenchymal Transition /Mesenchymal-to-Epithelial Transition drivers including ZEB1 (显示 ZEB1 抗体), GRHL2, CD24 (显示 CD24 抗体), and ESRP1 (显示 ESRP1 抗体), particularly in basal-like breast cancers, which are most similar to triple-negative breast cancer (TNBC) and are considered the most dangerous subtype
Data indicate a 'phenotypic stability factors' (PSFs) such as GRHL2 that couple to the core epithelial-to-mesenchymal transition (EMT (显示 ITK 抗体)) decision-making circuit (miR (显示 MLXIP 抗体)-200/ZEB (显示 ZEB1 抗体)) and stabilize hybrid epithelial/mesenchymal (hybrid E/M) E/M phenotype.
All of these processes involve epithelial-mesencyhmal transition (EMT (显示 ITK 抗体)), MET or a sequence of both, suggesting that the GRHL (显示 GHRL 抗体) factors((GRHL1 (显示 GRHL1 抗体), GRHL2 and GRHL3 (显示 GRHL3 抗体)), could potentially affect tumor initiation and progression via EMT (显示 ITK 抗体)
Silencing of GRHL2 expression in non-tumorigenic kidney cell line results in increased cell proliferation, increased resistance to apoptosis, as well as changes in the levels of selected proteins involved in the pathogenesis of clear cell renal cell carcinoma (显示 MOK 抗体) (ccRCC). These changes support the potential role for GRHL2 as a suppressor of ccRCC.
Results demonstrate a mechanistic role for GRHL2 in promoting anoikis through metabolic alterations.
GRHL2 maintained AR expression in multiple prostate cancer model systems, was required for cell proliferation, enhanced AR's transcriptional activity, and colocated with AR at specific sites on chromatin to regulate genes relevant to disease progression.
Studies indicate that Grainyhead-like transcription factor 2 (显示 HNF1B 抗体) (GRHL2) controls the expression of E-cadherin (CDH1 (显示 CDH1 抗体)) required for adherens junctions and possibly regulates the expression of claudin-4 (CLDN4 (显示 CLDN4 抗体)) in tight junctions.
results indicated GRHL2 might be a noise-induced hearing loss (NIHL) susceptibility gene, but the effect of POU4F3 (显示 POU4F3 抗体) on NIHL could only be detected when taking noise exposure into account and their effects were enhanced by higher levels of noise exposure
Results indicate GRHL2 as a novel progenitor cell maker in the developing pituitary that may contribute to progenitor cell function and maintenance.
GRHL2 promotes the epithelial nature of non-neural ectoderm during dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing epithelial-mesenchymal (EMT (显示 ITK 抗体)) transition through novel downstream EMT (显示 ITK 抗体) suppressors.
a Grhl2/Ovol2 (显示 OVOL2 抗体) network controls Cldn4 (显示 CLDN4 抗体) and Rab25 (显示 RAB25 抗体) expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia
Our findings reveal important pathophysiological differences between human pulmonary fibrosis and specific mouse models of fibrosis and support a crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity.
expression of GRHL2 is directly suppressed by the ZEB1 (显示 ZEB1 抗体), which in turn is a direct target for repression by GRHL2, suggesting that the EMT (显示 ITK 抗体) transcription factors GRHL2 and ZEB1 (显示 ZEB1 抗体) form a double negative regulatory feedback loop
Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT (显示 ITK 抗体) and tumor progression
the results indicate that Grhl2 regulates epithelial morphogenesis through transcriptional up-regulation of Cldn3 (显示 CLDN3 抗体) and Cldn4 (显示 CLDN4 抗体), as well as of Rab25 (显示 RAB25 抗体), which increases the Cldn4 (显示 CLDN4 抗体) protein and its localization at TJs
Grhl2 and Nkx2-1 (显示 NKX2-1 抗体) bind to each other's promoter in vivo, forming a positive feedback regulatory loop.
Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse
tissue closure defects in Grhl2 mutants are similar to that of AP-2alpha (显示 TFAP2A 抗体) null mutants and AP-2alpha (显示 TFAP2A 抗体) has been shown to bind to the promoter of E-cadherin (显示 CDH1 抗体)
The data showed that midbrain-hindbrain boundary maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets.
This work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss.
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
grainyhead-like 2 (Drosophila)
, transcription factor CP2-like 3
, brother of mammalian grainyhead
, grainyhead-like protein 2 homolog
, grainyhead like 2
, grainyhead-like 2
, grainyhead-like 2b protein