(Tubulin tyrosine Ligase-Like Family, Member 5 (TTLL5))
This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010].
Bompard, van Dijk, Cau, Lannay, Marcellin, Lawera, van der Laan, Rogowski: "CSAP Acts as a Regulator of TTLL-Mediated Microtubule Glutamylation." in: Cell reports, Vol. 25, Issue 10, pp. 2866-2877.e5, (2018) (PubMed).
Sergouniotis, Chakarova, Murphy, Becker, Lenassi, Arno, Lek, MacArthur, Bhattacharya, Moore, Holder, Robson, Wolfrum, Webster, Plagnol: "Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy." in: American journal of human genetics, Vol. 94, Issue 5, pp. 760-9, (2014) (PubMed).