Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
Lynch, Somerville, Spencer, Huang, Somervaille: "TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells." in: Cell death & disease, Vol. 4, pp. e573, (2013) (PubMed).
Song, Masison: "Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1)." in: The Journal of biological chemistry, Vol. 280, Issue 40, pp. 34178-85, (2005) (PubMed).
Yang, Roe, Cliff, Williams, Ladbury, Cohen, Barford: "Molecular basis for TPR domain-mediated regulation of protein phosphatase 5." in: The EMBO journal, Vol. 24, Issue 1, pp. 1-10, (2005) (PubMed).