TRPM8 抗体
(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
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60 results
TRPM8
适用: 大鼠
ELISA
宿主: 兔
Polyclonal
Carboxyfluorescein (CFS)
Latest Publications for our TRPM8 抗体
: "TRPM8 thermosensation in poikilotherms mediates both skin colour and locomotor performance responses to cold temperature." in: Communications biology, Vol. 6, Issue 1, pp. 127, (2023) (PubMed).: "TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells." in: Cancers, Vol. 14, Issue 9, (2022) (PubMed).
: "Gpr83 Tunes Nociceptor Function, Controlling Pain." in: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, (2022) (PubMed).
: "TRPM8 as an Anti-Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination." in: International journal of molecular sciences, Vol. 23, Issue 12, (2022) (PubMed).
: "Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 6, pp. 7483-7499, (2021) (PubMed).
: "TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration." in: Cell death & disease, Vol. 10, Issue 9, pp. 652, (2020) (PubMed).
: "Activation of Transient Receptor Potential Melastatin Subtype 8 Attenuates Cold-Induced Hypertension Through Ameliorating Vascular Mitochondrial Dysfunction." in: Journal of the American Heart Association, Vol. 6, Issue 8, (2018) (PubMed).
: "TRPM8 in the negative regulation of TNFα expression during cold stress." in: Scientific reports, Vol. 7, pp. 45155, (2017) (PubMed).
: "TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1." in: The Journal of cell biology, Vol. 216, Issue 7, pp. 2107-2130, (2017) (PubMed).
: "Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation." in: PLoS ONE, Vol. 9, Issue 9, pp. e107151, (2015) (PubMed).
Aliases for TRPM8 抗体
transient receptor potential cation channel subfamily M member 8 (TRPM8) 抗体transient receptor potential cation channel subfamily M member 8b L homeolog (trpm8b.L) 抗体
transient receptor potential cation channel subfamily M member 8 (Trpm8) 抗体
transient receptor potential cation channel, subfamily M, member 8 (Trpm8) 抗体
transient receptor potential cation channel, subfamily M, member 8 (TRPM8) 抗体
CMR1 抗体
LTrpC-6 抗体
ltrpc6 抗体
LTRPC6 抗体
Trp-p8 抗体
TRPM8 抗体
trpm8b 抗体
trpp8 抗体
TRPP8 抗体
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