This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009].
Zhang, Zhang, Cui, Ou, Han, Qin, Zhi, Wang: "TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination." in: Cell death & disease, Vol. 8, Issue 5, pp. e2831, (2017) (PubMed).