This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.
de Silva, Choudhury, Bailey, Harvey, Perrino, Hollis: "The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering." in: The Journal of biological chemistry, Vol. 282, Issue 14, pp. 10537-43, (2007) (PubMed).
Aliases for TREX2 抗体
three prime repair exonuclease 2 (TREX2) 抗体 three prime repair exonuclease 2 (Trex2) 抗体 RGD1562245 抗体