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TPSAB1 产品

(Tryptase alpha/beta 1 (TPSAB1))
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells\; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008].

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Featured TPSAB1 Categories

TPSAB1 抗体

High quality antibodies with extensive validation data.

TPSAB1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

TPSAB1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TPSAB1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7433105
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7426172
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7428305
Quantity 100 μL
Datasheet Datasheet

Recommended TPSAB1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (6)
  • (6)
Cat. No. ABIN6574250
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6960219
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6960221
Quantity 96 tests
Datasheet Datasheet

Recommended TPSAB1 蛋白

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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cynomolgus
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7275682
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323462
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3075013
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TPSAB1 Products

Rathore, Mantri, Aman, Syenina, Ooi, Jagaraj, Goh, Tissera, Wilder-Smith, Ng, Gubler, St John: "Dengue virus-elicited tryptase induces endothelial permeability and shock." in: The Journal of clinical investigation, Vol. 129, Issue 10, pp. 4180-4193, (2020) (PubMed).

Galiazzo, Giancola, Stanzani, Fracassi, Bernardini, Forni, Pietra, Chiocchetti: "Localization of cannabinoid receptors CB1, CB2, GPR55, and PPARα in the canine gastrointestinal tract." in: Histochemistry and cell biology, Vol. 150, Issue 2, pp. 187-205, (2018) (PubMed).

Wang, Chen, Xie, Lin, Wang, Yao, Zheng, Xu, Chen, He, Zhang: "Altered Expression of IFN-λ2 in Allergic Airway Disorders and Identification of Its Cell Origins." in: Mediators of inflammation, Vol. 2016, pp. 5759496, (2016) (PubMed).

Moreno, Puig, Serrano, Moreno-Navarrete, Ortega, Ricart, Fernandez-Real: "Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects." in: PLoS ONE, Vol. 9, Issue 5, pp. e97014, (2015) (PubMed).

Berdún, Bombuy, Estrada, Mans, Rychter, Clavé, Vergara: "Peritoneal mast cell degranulation and gastrointestinal recovery in patients undergoing colorectal surgery." in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, Vol. 27, Issue 6, pp. 764-74, (2015) (PubMed).

Zhu, Pan, Wang, Liu, Chen, Xu, Liao, Hu: "Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis." in: International immunopharmacology, Vol. 28, Issue 1, pp. 507-12, (2015) (PubMed).

Lewicki, Siebert, Marek-Trzonkowska, Masiewicz, Kolinski, Reiwer-Gostomska, Targonski, Trzonkowski: "Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report." in: Mediators of inflammation, Vol. 2015, pp. 395173, (2015) (PubMed).

Yan, Yao, Bao, Shi, Yu, Yin, Liu: "Effect of Auricular Acupressure on Uremic Pruritus in Patients Receiving Hemodialysis Treatment: A Randomized Controlled Trial." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 593196, (2015) (PubMed).

Naoi, Hayashi, Inoue, Tanikawa, Igarashi, Nagasaka, Kage, Takikawa, Sugiyama, Inui, Nagai, Kusuhara: "Improved liver function and relieved pruritus after 4-phenylbutyrate therapy in a patient with progressive familial intrahepatic cholestasis type 2." in: The Journal of pediatrics, Vol. 164, Issue 5, pp. 1219-1227.e3, (2014) (PubMed).

El Gamal, AlSaid, Raish, Al-Sohaibani, Al-Massarani, Ahmad, Hefnawy, Al-Yahya, Basoudan, Rafatullah: "Beetroot (Beta vulgaris L.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model." in: Mediators of inflammation, Vol. 2014, pp. 983952, (2014) (PubMed).

Synonyms and alternative names related to TPSAB1

tryptase alpha/beta 1 (TPSAB1), tryptase (MCT7), tryptase alpha/beta 1 (tpsab1), tryptase beta 2 (gene/pseudogene) (TPSB2), tryptase alpha/beta 1 (Tpsab1), tryptase beta 2 (Tpsb2), AV011504, Mcp-6, Mcp-7, Mcp6, Mcp7, Mcpt6, Mcpt7, MMCP-6, MMCP-7, PMCT7, rMCP-7, TPS1, TPS2, tpsab1, TPSB1, tryptaseB, tryptaseC

Protein level used designations for TPSAB1

  • mast cell alpha II tryptase
  • mast cell beta I tryptase
  • tryptase I
  • tryptase alpha II
  • tryptase alpha-1
  • tryptase alpha/beta-1
  • tryptase beta 1
  • tryptase beta I
  • tryptase beta-1
  • tryptase-1
  • tryptase-I
  • tryptase-III
  • tryptase alpha/beta 1
  • mast cell tryptase beta II
  • mast cell tryptase beta III
  • tryptase beta-2
  • mast cell protease 7
  • mast cell-restricted serine protease 7
  • tryptase
  • MMCP-7
  • tryptase, skin
  • mast cell protease 6
  • tryptase-2
  • rMCP-6
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