TPMT 抗体
(Thiopurine S-Methyltransferase (TPMT))
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq, Jul 2008].
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Latest Publications for our TPMT 抗体
: "Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15054-65, (2012) (PubMed).: "S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts." in: Biochemical pharmacology, Vol. 77, Issue 12, pp. 1845-53, (2009) (PubMed).
: "A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types." in: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, Vol. 69, Issue 1, pp. 23-30, (2008) (PubMed).
: "Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 26, pp. 9394-9, (2005) (PubMed).
: "Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein." in: Nature, Vol. 375, Issue 6533, pp. 691-4, (1995) (PubMed).
Aliases for TPMT 抗体
thiopurine S-methyltransferase L homeolog (tpmt.L) 抗体thiopurine S-methyltransferase, tandem duplicate 2 (tpmt.2) 抗体
thiopurine S-methyltransferase TpmT (tpmT) 抗体
thiopurine S-methyltransferase (MCA0794) 抗体
thiopurine S-methyltransferase (Pnap_4948) 抗体
thiopurine S-methyltransferase (Hhal_1383) 抗体
thiopurine S-methyltransferase (TK90_1044) 抗体
thiopurine S-methyltransferase (Slit_1144) 抗体
thiopurine S-methyltransferase (Tint_0842) 抗体
Thiopurine S-methyltransferase (Fbal_3334) 抗体
thiopurine S-methyltransferase (Celly_3188) 抗体
thiopurine S-methyltransferase (Weevi_1737) 抗体
Thiopurine S-methyltransferase (Psefu_2696) 抗体
Thiopurine S-methyltransferase (Metme_3860) 抗体
thiopurine methyltransferase (Tpmt) 抗体
thiopurine S-methyltransferase (TPMT) 抗体
thiopurine S-methyltransferase (Tpmt) 抗体
AW106912 抗体
MGC84277 抗体
NHLRC1 抗体
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