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TPCN2 产品

(Two Pore Segment Channel 2 (TPCN2))
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009].

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Featured TPCN2 Categories

TPCN2 抗体

High quality antibodies with extensive validation data.

TPCN2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

TPCN2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TPCN2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN570776
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7043872
Quantity 25 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC
Validations
  • (1)
Cat. No. ABIN351016
Quantity 500 μg
Datasheet Datasheet

Recommended TPCN2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN6199931
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN6199932
Quantity 96 tests
Datasheet Datasheet

Recommended TPCN2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3116758
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3074787
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3125363
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TPCN2 Products

Lin, Izar, Wang, Yapp, Mei, Shah, Santagata, Sorger: "Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes." in: eLife, Vol. 7, (2019) (PubMed).

Lee, Tong, Cheng, Hung, Cheung: "Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology." in: Scientific reports, Vol. 6, pp. 20282, (2016) (PubMed).

Favia, Desideri, Gambara, DAlessio, Ruas, Esposito, Del Bufalo, Parrington, Ziparo, Palombi, Galione, Filippini: "VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 44, pp. E4706-15, (2014) (PubMed).

Arndt, Castonguay, Arlt, Meyer, Hassan, Borth, Zierler, Wennemuth, Breit, Biel, Wahl-Schott, Gudermann, Klugbauer, Boekhoff: "NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa." in: Molecular biology of the cell, Vol. 25, Issue 6, pp. 948-64, (2014) (PubMed).

Calcraft, Ruas, Pan, Cheng, Arredouani, Hao, Tang, Rietdorf, Teboul, Chuang, Lin, Xiao, Wang, Zhu, Lin, Wyatt, Parrington, Ma, Evans, Galione, Zhu: "NAADP mobilizes calcium from acidic organelles through two-pore channels." in: Nature, Vol. 459, Issue 7246, pp. 596-600, (2009) (PubMed).

Synonyms and alternative names related to TPCN2

two pore segment channel 2 (tpcn2), two pore segment channel 2 (Tpcn2), two pore segment channel 2 (TPCN2), two pore segment channel 2 L homeolog (tpcn2.L), two pore calcium channel protein 2 (LOC100444397), BC025890, D830047E22Rik, fi42c05, im:7140344, MGC115225, SHEP10, TPC2, wu:fi42c05, zgc:152898

Protein level used designations for TPCN2

  • two pore calcium channel protein 2
  • voltage-dependent calcium channel protein TPC2
  • two pore segment channel 2
  • two pore calcium channel protein 2-like
  • two-pore calcium channel protein 2
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