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Human Monoclonal IKBKE Primary Antibody for ELISA, WB - ABIN969213
Boehm, Zhao, Yao, Kim, Firestein, Dunn, Sjostrom, Garraway, Weremowicz, Richardson, Greulich, Stewart, Mulvey, Shen, Ambrogio, Hirozane-Kishikawa, Hill, Vidal, Meyerson, Grenier, Hinkle, Root et al.: Integrative genomic approaches identify IKBKE as a breast cancer oncogene. ... in Cell 2007
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Human Polyclonal IKBKE Primary Antibody for ELISA, WB - ABIN4224388
Rajsbaum, Versteeg, Schmid, Maestre, Belicha-Villanueva, Martínez-Romero, Patel, Morrison, Pisanelli, Miorin, Laurent-Rolle, Moulton, Stein, Fernandez-Sesma, tenOever, García-Sastre: Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. in Immunity 2014
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Human Monoclonal IKBKE Primary Antibody for ELISA, WB - ABIN966381
Luttjeboer, Harada, Hughes, Johnson, Lilford, Mol: Tubal flushing for subfertility. in Cochrane database of systematic reviews (Online) 2007
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Human Polyclonal IKBKE Primary Antibody for ICC, IF - ABIN4324307
Sun, Sammut, Wang, Kurihara, Windle, Roodman, Galson: TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013
Human Polyclonal IKBKE Primary Antibody for ELISA, IHC - ABIN4324306
Péant, Diallo, Lessard, Delvoye, Le Page, Saad, Mes-Masson: Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer. in Molecular cancer research : MCR 2007
Studied association between nuclear factor kappa beta1/IKK epsilon (NF-kappaB1 (显示 NFKB1 抗体)/IKKepsilon) gene expression and clinical activity in rheumatoid arthritis (RA). Found there were significant differences in NF-kappaB1 (显示 NFKB1 抗体) and IKKepsilon gene expression (P = .001 and P = .029, respectively) between RA patients with clinical activity and clinical remission.
IKBKE plays a pivotal role in regulating cell proliferation, invasion and epithelial-mesenchymal transition of malignant glioma cells in vitro and in vivo by impacting on the Hippo pathway.
Inverse association between IKKepsilon and lymph node metastasis in breast cancer.
YPEL5 silencing enhanced the induction of IFNB1 (显示 IFNB1 抗体) by pattern recognition receptors and phosphorylation of TBK1 (显示 TBK1 抗体)/IKBKE kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE.
results demonstrate that Sphingosine 1-phosphate lyase (SPL (显示 SGPL1 抗体)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL (显示 SGPL1 抗体), which provides a mechanistic understanding of the pro-IFN activity of SPL (显示 SGPL1 抗体)
Virus-activated kinase IKKepsilon phosphorylated YAP (显示 YAP1 抗体) at Ser403 and thereby triggered degradation of YAP (显示 YAP1 抗体) in lysosomes and, consequently, relief of YAP (显示 YAP1 抗体)-mediated inhibition of the cellular antiviral response.
We then determined that YAP1 (显示 YAP1 抗体) negatively regulates miR (显示 MLXIP 抗体)-let-7b/i by overexpressing and silencing YAP1 (显示 YAP1 抗体) expression. In addition, miR (显示 MLXIP 抗体)-let-7b/i feedback decreases the expression of IKBKE and YAP1 (显示 YAP1 抗体) and suppresses the transportation of YAP1 (显示 YAP1 抗体) located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 (显示 YAP1 抗体) upward arrow-->miR (显示 MLXIP 抗体)-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...
our findings highlight the functional importance of IKBKE in pancreatic cancer
we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma
demonstrate a key role of TBK1 (显示 TBK1 抗体)/IKKepsilon in the survival and proliferation of HTLV-1-transformed T cells
IKKepsilon promotes NFATc1 (显示 NFATC1 抗体) phosphorylation and inhibits T cell responses, identifying IKKepsilon as a crucial negative regulator of T cell activation and a potential target for immunotherapy.
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
Suggest that by reducing production of cAMP in adipocytes, PDE3B (显示 PDE3B 抗体), IKKepsilon and TBK1 (显示 TBK1 抗体) may contribute to the repression of energy expenditure during obesity.
A role for APPL1 (显示 APPL1 抗体) in TLR3 (显示 TLR3 抗体)/4-dependent TBK1 (显示 TBK1 抗体) and IKKepsilon activation in macrophages.
The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response
tic (显示 ARNTL 抗体) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (显示 NLRP3 抗体) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.
novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity
miR (显示 MLXIP 抗体)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (显示 NFKB1 抗体) pathway by abolishing IKK-beta (显示 IKBKB 抗体) and IKK-epsilon activity.
IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon-like
, I-kappa-B kinase epsilon
, IKK-related kinase epsilon
, inducible I kappa-B kinase
, inducible IkappaB kinase
, inhibitor of kappaB kinase epsilon
, inducible IKappaB kinase