TLR3 抗体
(Toll-Like Receptor 3 (TLR3))
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008].
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Latest Publications for our TLR3 抗体
: "Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations." in: The Journal of allergy and clinical immunology, Vol. 143, Issue 1, pp. 114-125.e4, (2019) (PubMed).: "Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 5, pp. 6197-6208, (2019) (PubMed).
: "Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis." in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Vol. 19, Issue 1, pp. 149-157, (2019) (PubMed).
: "Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells." in: Veterinary and comparative oncology, Vol. 17, Issue 2, pp. 184-193, (2019) (PubMed).
: "Activation of Toll-like receptor 3 promotes pathological corneal neovascularization by enhancement of SDF-1-mediated endothelial progenitor cell recruitment." in: Experimental eye research, Vol. 178, pp. 177-185, (2019) (PubMed).
: "Calcium/Calmodulin-Dependent Protein Kinase IV Mediates IFN-γ-Induced Immune Behaviors in Skeletal Muscle Cells." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 46, Issue 1, pp. 351-364, (2018) (PubMed).
: "Substance P represents a novel first-line defense mechanism in the nose." in: The Journal of allergy and clinical immunology, (2017) (PubMed).
: "Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury." in: Hepatology (Baltimore, Md.), Vol. 65, Issue 4, pp. 1336-1351, (2017) (PubMed).
: "The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 64, Issue 8, pp. 470-82, (2017) (PubMed).
: "Migration ability and Toll-like receptor expression of human mesenchymal stem cells improves significantly after three-dimensional culture." in: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 323-328, (2017) (PubMed).
Aliases for TLR3 抗体
toll like receptor 3 (TLR3) 抗体toll-like receptor 3 (Tlr3) 抗体
toll like receptor 3 (Tlr3) 抗体
toll-like receptor 3 (tlr3) 抗体
AI957183 抗体
CD283 抗体
IIAE2 抗体
zgc:123006 抗体
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