(Tight Junction Protein 2 (Zona Occludens 2) (TJP2))
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Chen, Chen, Wang, Lin, Chen, Tsai, Chen: "Downregulation of tight junction protein zonula occludens-2 and urothelium damage in a cyclophosphamide-induced mouse model of cystitis." in: Taiwanese journal of obstetrics & gynecology, Vol. 57, Issue 3, pp. 399-406, (2018) (PubMed).
Chen, Chen, Chen, Wang, Chen: "A promising protein responsible for overactive bladder in ovariectomized mice." in: Taiwanese journal of obstetrics & gynecology, Vol. 56, Issue 2, pp. 196-203, (2017) (PubMed).
González-Andrades, Garzón, Gascón, Muñoz-Avila, Sánchez-Quevedo, Campos, Alaminos: "Sequential development of intercellular junctions in bioengineered human corneas." in: Journal of tissue engineering and regenerative medicine, Vol. 3, Issue 6, pp. 442-9, (2009) (PubMed).