TIGAR 抗体
(TP53 induced glycolysis regulatory phosphatase (TIGAR))
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008].
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Latest Publications for our TIGAR 抗体
: "The regulation of energy generating metabolic pathways by p53." in: Cancer biology & therapy, Vol. 5, Issue 12, pp. 1610-3, (2007) (PubMed).: "TIGAR, a p53-inducible regulator of glycolysis and apoptosis." in: Cell, Vol. 126, Issue 1, pp. 107-20, (2006) (PubMed).
: "Role of Wnt10b and C/EBPalpha in spontaneous adipogenesis of 243 cells." in: Biochemical and biophysical research communications, Vol. 302, Issue 1, pp. 12-6, (2003) (PubMed).
: "TP53: a key gene in human cancer." in: Biochimie, Vol. 84, Issue 1, pp. 83-93, (2002) (PubMed).
Aliases for TIGAR 抗体
Trp53 induced glycolysis repulatory phosphatase (Tigar) 抗体AA793651 抗体
AI595337 抗体
C79710 抗体
C85509 抗体
Tigar 抗体
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