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T-Box 5 产品

(T-Box 5 (TBX5))

Categories

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

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Featured T-Box 5 Categories

T-Box 5 抗体

High quality antibodies with extensive validation data.

T-Box 5 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended T-Box 5 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, RNAi
Validations
  • (3)
  • (3)
Cat. No. ABIN563098
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7239203
Quantity 200 μL
Datasheet Datasheet

Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN6741551
Quantity 100 μL
Datasheet Datasheet

Recommended T-Box 5 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6221767
Quantity 96 tests
Datasheet Datasheet

Recommended T-Box 5 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322302
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322304
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423756
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our T-Box 5 Products

Karakikes, Termglinchan, Cepeda, Lee, Diecke, Hendel, Itzhaki, Ameen, Shrestha, Wu, Ma, Shao, Seeger, Woo, Wilson, Matsa, Porteus, Sebastiano, Wu: "A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases." in: Circulation research, Vol. 120, Issue 10, pp. 1561-1571, (2017) (PubMed).

Ma, Yang, Mahida, Zhao, Chen, Zhang, Sun, Yao, Zhang, Zheng, Dong, Feng, Zhang, Sun, Li, Wang, Cao, Benjamin, Ellinor, Li, Tian: "TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians." in: Cardiovascular research, Vol. 109, Issue 3, pp. 442-50, (2016) (PubMed).

Kokkinopoulos, Ishida, Saba, Ruchaya, Cabrera, Struebig, Barnes, Terry, Kaneko, Shintani, Coppen, Shiratori, Ameen, Mein, Hamada, Suzuki, Yashiro: "Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo." in: PLoS ONE, Vol. 10, Issue 10, pp. e0140831, (2015) (PubMed).

Tong, Zu, Li, Li, Ying, Yang, Wang, He, Liu, Zhu, Chen, Lin, Zhang: "Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish." in: Nature communications, Vol. 5, pp. 3153, (2014) (PubMed).

Baban, Pitto, Pulignani, Cresci, Mariani, Gambacciani, Digilio, Pongiglione, Albanese: "Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation." in: American journal of medical genetics. Part A, Vol. 164A, Issue 6, pp. 1419-24, (2014) (PubMed).

Hartung, Schwanke, Haase, David, Franz, Martin, Zweigerdt: "Directing cardiomyogenic differentiation of human pluripotent stem cells by plasmid-based transient overexpression of cardiac transcription factors." in: Stem cells and development, Vol. 22, Issue 7, pp. 1112-25, (2013) (PubMed).

Zhang, Huang, Zuo, Chen, Wang: "Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling." in: Aquatic toxicology (Amsterdam, Netherlands), Vol. 142-143, pp. 26-32, (2013) (PubMed).

Lian, Zhang, Azarin, Zhu, Hazeltine, Bao, Hsiao, Kamp, Palecek: "Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions." in: Nature protocols, Vol. 8, Issue 1, pp. 162-75, (2012) (PubMed).

Lu, Tsai, Choo, Yeh, Tang, Yang, Lee, Lu: "Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos." in: Journal of biomedical science, Vol. 18, pp. 73, (2011) (PubMed).

Ghosh, Song, Packham, Buxton, Robinson, Ronksley, Self, Bonser, Brook: "Physical interaction between TBX5 and MEF2C is required for early heart development." in: Molecular and cellular biology, Vol. 29, Issue 8, pp. 2205-18, (2009) (PubMed).

Synonyms and alternative names related to T-Box 5

T-box 5 (TBX5), T-box 5 (tbx5), T-box 5 L homeolog (tbx5.L), T-box 5 (Tbx5), T-box 5a (tbx5a), HOS, tbx-5, TBX5, tbx5, tbx5.1, xtbx-5, xtbx5, zf-tbx5, zTbx5

Protein level used designations for T-Box 5

  • T-box 5
  • T-box protein 5
  • T-box transcription factor 5
  • T-box transcription factor TBX5
  • T-box transcription factor TBX5-like
  • t-box transcription factor TBX5-like
  • T-box gene 5
  • T-box gene 5.1
  • T-box transcription factor TBX5-A
  • etID310031.5
  • heartstrings
  • hst
  • zftbx5a
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