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T-Bet 产品

(T-Bet)

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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008].

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Featured T-Bet Categories

T-Bet 抗体

High quality antibodies with extensive validation data.

T-Bet ELISA试剂盒

Reliable ELISA kits for a wide range of species.

T-Bet 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended T-Bet 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7442723
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, ICC, IF
Validations
  • (3)
Cat. No. ABIN6265489
Quantity 100 μL
Datasheet Datasheet
Reactivity Bat, Cow, Dog, Guinea Pig, Human, Monkey, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN6735814
Quantity 100 μL
Datasheet Datasheet

Recommended T-Bet ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970533
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970532
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959837
Quantity 96 tests
Datasheet Datasheet

Recommended T-Bet 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322294
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1322292
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125305
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our T-Bet Products

Ding, Liu, Zeng, Zhu, Liu, Jiang, Huang: "Glycogen synthase kinase‑3β inhibitor reduces LPS‑induced acute lung injury in mice." in: Molecular medicine reports, Vol. 16, Issue 5, pp. 6715-6721, (2018) (PubMed).

Rueda, Presicce, Jackson, Miller, Kallapur, Jobe, Chougnet: "Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 9, pp. 3706-15, (2016) (PubMed).

Bang, Seo, Seo, Jo, Jung, Yu, Park, Park: "Bacillus subtilis KCTC 11782BP-Produced Alginate Oligosaccharide Effectively Suppresses Asthma via T-Helper Cell Type 2-Related Cytokines." in: PLoS ONE, Vol. 10, Issue 2, pp. e0117524, (2015) (PubMed).

Liu, Wang, Ming, Song, Zhang, Chen, Zeng, Mao: "S100A9: A Potential Biomarker for the Progression of Non-Alcoholic Fatty Liver Disease and the Diagnosis of Non-Alcoholic Steatohepatitis." in: PLoS ONE, Vol. 10, Issue 5, pp. e0127352, (2015) (PubMed).

Hendriks, van der Velden, Wolberink, Seyger, Schalkwijk, Zeeuwen, de Jong, Pasch, van Erp, van de Kerkhof: "The effect of adalimumab on key drivers in the pathogenesis of psoriasis." in: The British journal of dermatology, Vol. 170, Issue 3, pp. 571-80, (2014) (PubMed).

Miao, Run-Ming, Yi: "T-Bet Mediated Anti-Neoplastic Effects of Dendritic Cell-Cytokine Induced Killer Cells in vitro." in: Iranian journal of pediatrics, Vol. 22, Issue 1, pp. 43-51, (2012) (PubMed).

Bachmann, Scheiermann, Härdle, Pfeilschifter, Mühl: "IL-36γ/IL-1F9, an innate T-bet target in myeloid cells." in: The Journal of biological chemistry, Vol. 287, Issue 50, pp. 41684-96, (2012) (PubMed).

Nyirenda, Sanvito, Darlington, OBrien, Zhang, Constantinescu, Bar-Or, Gran: "TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 5, pp. 2278-90, (2011) (PubMed).

Mansfield, Holtan, Grotz, Allred, Jakub, Erickson, Markovic: "Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 24, Issue 4, pp. 487-94, (2011) (PubMed).

Peng: "The T-box transcription factor T-bet in immunity and autoimmunity." in: Cellular & molecular immunology, Vol. 3, Issue 2, pp. 87-95, (2006) (PubMed).

Synonyms and alternative names related to T-Bet

T-box 21 (TBX21), T-box 21 (Tbx21), T-bet, T-PET, TBET, Tbet, TBLYM, Tblym, TBT1

Protein level used designations for T-Bet

  • T-box expressed in T cells
  • T-box protein 21
  • T-box transcription factor TBX21
  • T-cell-specific T-box transcription factor T-bet
  • transcription factor TBLYM
  • t-box transcription factor TBX21
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