(TRAF Family Member-Associated NFKB Activator (TANK))
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Qian, Fan, Liu, Wu, Zhang, Cui, Zhou, Hu, Wei, Chen, Li, Qian: "Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage." in: Journal of virology, Vol. 91, Issue 16, (2017) (PubMed).
Tanaka, Chen: "STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway." in: Science signaling, Vol. 5, Issue 214, pp. ra20, (2012) (PubMed).
Guo, Cheng: "Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK." in: The Journal of biological chemistry, Vol. 282, Issue 16, pp. 11817-26, (2007) (PubMed).
Chariot, Leonardi, Muller, Bonif, Brown, Siebenlist: "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37029-36, (2002) (PubMed).
Pomerantz, Baltimore: "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase." in: The EMBO journal, Vol. 18, Issue 23, pp. 6694-704, (2000) (PubMed).
Aliases for TANK 抗体
TRAF family member associated NFKB activator (TANK) 抗体 TRAF family member-associated Nf-kappa B activator (Tank) 抗体 TRAF family member-associated NFKB activator (Tank) 抗体 TRAF family member associated NFKB activator (Tank) 抗体 TRAF family member-associated NFKB activator (tank) 抗体 TRAF family member associated NFKB activator L homeolog (tank.L) 抗体 C86182 抗体 E430026L09Rik 抗体 I-TRAF 抗体 i-traf 抗体 ITRAF 抗体 tank 抗体 TRAF2 抗体 traf2 抗体 zgc:153048 抗体