(Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3))
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011].
Nahm, Kim, Lee, Cho, Choi, Yoon, Han, Park et al.: "Transforming acidic coiled-coil-containing protein 3 (TACC3) overexpression in hepatocellular carcinomas is associated with "stemness" and epithelial-mesenchymal transition-related marker expression ..." in: Tumour biology, (2015) (PubMed).
Guo, Partch, Key, Card, Pashkov, Patel, Bruick, Wurdak, Gardner: "Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules." in: ACS chemical biology, Vol. 8, Issue 3, pp. 626-35, (2013) (PubMed).