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topographic separation of the presynaptic terminals of adjacent nociceptive neurons requires different levels of Trim9, an evolutionarily conserved signaling molecule
TRIM9s undergoes Lys (显示 LYZ 蛋白)-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1 (显示 TBK1 蛋白), leading to the activation of IRF3 (显示 IRF3 蛋白) signaling.
Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC (显示 DCC 蛋白) blocks the interaction with and phosphorylation of FAK (显示 PTK2 蛋白).
TRIM9 is a brain-specific (显示 CALY 蛋白) negative regulator of the NF-kappaB (显示 NFKB1 蛋白) pro-inflammatory signalling pathway.
These results suggest that TRIM9 plays an important role in the regulation of neuronal functions and participates in pathological process of Lewy body disease through its ligase activity.
Trim9 mediates cellular movement and migration in macrophages as well as neurons.
Adult-born dentate granule cells lacking Trim9 exhibited excessive dendritic arborization and mislocalization of cell bodies in vivo
a gradient of TRIM9-mediated ubiquitination of VASP (显示 VASP 蛋白) creates a filopodial stability gradient during axon turning
TRIM9 is expressed in the mouse embryonic and adult nervous system
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms.
tripartite motif-containing 9
, tripartite motif containing 9
, anomalies in sensory axon patterning
, tripartite motif protein 9
, E3 ubiquitin-protein ligase TRIM9
, RING finger protein 91
, homolog of rat RING finger Spring
, tripartite motif-containing protein 9
, SNAP-25-interacting RING finger protein