抗Human CYP3A5 抗体:
抗Mouse (Murine) CYP3A5 抗体:
抗Rat (Rattus) CYP3A5 抗体:
Human Monoclonal CYP3A5 Primary Antibody for IHC (p), ELISA - ABIN533616
McCune, Risler, Phillips, Thummel, Blough, Shen: Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. in Drug metabolism and disposition: the biological fate of chemicals 2005
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1:1.25 conversion should be used for CYP3A5 expressors and 1:1 conversion for other patients.
Comparison with the CYP3A5-ritonavir complex confirmed conserved CYP3A5 structural features and indicated differences in plasticity between CYP3A4 and CYP3A5 that favor alternative ritonavir conformations.
The donor and recipient CYP3A5*3 polymorphism influences tacrolimus pharmacokinetics in the first month post-transplantation, whereas the association with recipient ABCB1 3435 C > T is inconclusive.
Kidney donor non-expressor genotype is a risk factor for calcineurin inhibitor nephrotoxicity after transplantation
Clinical characteristics and CYP3A5/CYP3A4/POR genotypes were collected.
There was no significant association between Tac-related nephrotoxicity and donor CYP3A5 and ABCB1 genotype.
No significant association was identified between CYP3A5*3 and the 1-year outcome of patients with ischemic stroke.
CP3A5 genetic variants were not associated with treatment resistance when compared to responders to clopidogrel therapy.
The authors results show that CYP3A5 polymorphism had a significant impact on tacrolimus pharmacokinetics in this population.
CYP3A5 polymorphism is associated with kidney graft rejection.
in skin, gene expression of CYP3A5 was significantly greater than that of CYP3A4
Concerning CEP72, our results are in line with the findings from the St Jude cohort of children treated for ALL with higher vincristine doses during chronic treatment. Larger high-throughput genetic analyses may be warranted to evaluate variants in other candidate genes such as CYP3A5 and reveal new nonpreviously reported alleles that may be peculiar to this region of the world
CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer.
ABCB1 C1236T, ABCB1 G2677 T/A genotype and BMI are probably the factors influencing the clinical efficacy of tacrolimus in treating patients with nephrotic syndrome.
Polymorphism in CYP3A5 gene is associated with reduced sorafenib metabolism and increased toxicity in Chinese hepatocellular carcinoma patients.
Therapeutic drug monitoring and detection of CYP3A5 gene polymorphism was essential for dosage optimization in patients with myasthenia gravis
CYP3A5 genotype is the single most important determinant of tacrolimus metabolite.
non-relapse and relapse according to relapse and non-relapse, then the relation between the SNP of CYP3A5 gene and MRD1 gene loci and the risk of cytogenetic relapse in chronic myeloid leukemia patients
Use of CYP3A5 genotyping to guide the initial dosing of Tac when converting the immunosuppression therapy from CsA to Tac.
Contrasting results have been reported on the role of rs628031 and rs683369 polymorphisms of SLC22A1 and rs776746 of CYP3A5 on imatinib treatment response in patients with chronic myeloid leukemia. The present meta-analysis supports the association of SLC22A1 and CYP3A5 genotypes with clinical imatinib response rates of chronic myeloid leukemia patients. [review]
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.
cytochrome P450 3A5
, aryl hydrocarbon hydroxylase
, cytochrome P450 HLp2
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
, cytochrome P450-PCN3
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, xenobiotic monooxygenase