STAT3 蛋白
(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| STAT3 Protein (His tag) | 小鼠 | Insect Cells |
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| STAT3 Protein (AA 1-770) (GST tag) | 小鼠 | Bacteria |
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| STAT3 Protein (AA 1-770) (His tag) | 小鼠 | Eukaryota |
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| STAT3 Protein (AA 1-770) (His tag) | 人 | Eukaryota |
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| STAT3 Protein (AA 1-770) (GST tag) | 人 | Bacteria |
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| STAT3 蛋白 | 人, 大鼠, 小鼠 | 大肠杆菌（E. Coli） |
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| STAT3 Protein (GST tag) | 人 | 大肠杆菌（E. Coli） |
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| STAT3 Protein (His tag) | 人 | 大肠杆菌（E. Coli） |
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| STAT3 Protein (His tag) | 人 | Insect Cells |
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Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 小鼠
- 宿主
- Insect Cells
- 蛋白类型
- Recombinant
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
Protein
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 95 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- Insect Cells
- 蛋白类型
- Recombinant
Latest Publications for our STAT3 蛋白
: "ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3." in: Oncogene, Vol. 39, Issue 39, pp. 6203-6217, (2021) (PubMed).
: "AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer." in: Theranostics, Vol. 8, Issue 3, pp. 676-692, (2018) (PubMed).
: "KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer." in: Molecular cancer, Vol. 13, pp. 176, (2014) (PubMed).
: "Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening." in: Methods (San Diego, Calif.), Vol. 71, pp. 38-43, (2014) (PubMed).
: "AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer." in: Theranostics, Vol. 8, Issue 3, pp. 676-692, (2018) (PubMed).
: "KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer." in: Molecular cancer, Vol. 13, pp. 176, (2014) (PubMed).
: "Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening." in: Methods (San Diego, Calif.), Vol. 71, pp. 38-43, (2014) (PubMed).
Aliases for STAT3 蛋白
signal transducer and activator of transcription 3 (STAT3) 蛋白signal transduction and activation of transcription 3 (stat3) 蛋白
signal transducer and activator of transcription 3 (stat3) 蛋白
signal transducer and activator of transcription 3 (Stat3) 蛋白
signal transducer and activator of transcription 3, gene 1 L homeolog (stat3.1.L) 蛋白
signal transducer and activator of transcription 3 (acute-phase response factor) (stat3) 蛋白
1110034C02Rik 蛋白
Aprf 蛋白
APRF 蛋白
aprf 蛋白
AW109958 蛋白
HIES 蛋白
hies 蛋白
stat3 蛋白
wu:fc15d02 蛋白
wu:fl59g06 蛋白
Xstat3 蛋白
z-Stat3 蛋白
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