Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008].
Kouprina, Pavlicek, Noskov, Solomon, Otstot, Isaacs, Carpten, Trent, Schleutker, Barrett, Jurka, Larionov: "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27." in: Genome research, Vol. 15, Issue 11, pp. 1477-86, (2005) (PubMed).
Westbrook, Schoppee, Diekman, Klotz, Allietta, Hogan, Slingluff, Patterson, Frierson, Irvin, Flickinger, Coppola, Herr: "Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 1 Pt 1, pp. 101-12, (2004) (PubMed).
Kouprina, Mullokandov, Rogozin, Collins, Solomon, Otstot, Risinger, Koonin, Barrett, Larionov: "The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 9, pp. 3077-82, (2004) (PubMed).
Zendman, Zschocke, van Kraats, de Wit, Kurpisz, Weidle, Ruiter, Weiss, van Muijen: "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines." in: Gene, Vol. 309, Issue 2, pp. 125-33, (2003) (PubMed).
Aliases for SPANXC 抗体
SPANX family member C (SPANXC) 抗体 C 抗体 CT11.3 抗体 CTp11 抗体 SPANX-C 抗体