SOCS2 产品
(Suppressor of Cytokine Signaling 2 (SOCS2))
Categories
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].
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Featured SOCS2 Categories
SOCS2 抗体
High quality antibodies with extensive validation data.
SOCS2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
SOCS2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SOCS2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7443314
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7270641
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, ICC, IF
Validations
- (4)
Cat. No.
ABIN6265216
Quantity
100 μL
Datasheet
Datasheet
Recommended SOCS2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970481
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970480
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959766
Quantity
96 tests
Datasheet
Datasheet
Recommended SOCS2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1320927
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320929
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3077005
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SOCS2 Products
: "Expression of SOCS2 mRNA and protein in the ischemic core and penumbra after transient focal cerebral ischemia in rats." in: Cell and tissue research, Vol. 364, Issue 1, pp. 67-81, (2016) (PubMed).: "Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer." in: British journal of cancer, Vol. 111, Issue 4, pp. 726-35, (2014) (PubMed).
: "Expression of SOCSs in human prostate cancer and their association in prognosis." in: Molecular and cellular biochemistry, Vol. 381, Issue 1-2, pp. 51-9, (2013) (PubMed).
: "STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 1, pp. 127-39, (2012) (PubMed).
: "Inhibition of growth hormone signaling by the fasting-induced hormone FGF21." in: Cell metabolism, Vol. 8, Issue 1, pp. 77-83, (2008) (PubMed).
: "Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression." in: Physiological genomics, Vol. 32, Issue 2, pp. 254-63, (2008) (PubMed).
: "Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2." in: Neuroscience, Vol. 132, Issue 3, pp. 673-87, (2005) (PubMed).
: "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)." in: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 6, pp. 1394-406, (2002) (PubMed).
: "Regulation of SOCS-1 expression by translational repression." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21596-604, (2000) (PubMed).
: "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35553-61, (2000) (PubMed).
Synonyms and alternative names related to SOCS2
suppressor of cytokine signaling 2 (SOCS2), suppressor of cytokine signaling 1 (Socs1), suppressor of cytokine signaling 2 (Socs2), suppressor of cytokine signaling 2 (socs2), death domain-containing protein CRADD (LOC100716104), suppressor of cytokine signaling 2 S homeolog (socs2.S), 8030460M17, AI527257, AW108012, CIS2, cis2, Cish1, Cish2, cish2, Cradd, D130043N08Rik, hg, JAB, si:dkey-202b22.1, Socs-1, SOCS-2, Socs-2, socs-2, socs2, Socs2, SSI-2, ssi-2, SSI2, ssi2, STATI2, stati2Protein level used designations for SOCS2
- CIS-2
- STAT induced STAT inhibitor-2
- STAT-induced STAT inhibitor 2
- STAT-induced STAT inhibitor-2
- cytokine-inducible SH2 protein 2
- suppressor of cytokine signaling-2
- cytokine inducible SH2-containing protein 1
- cytokine inducible SH2-containing protein 2
- SOCS-2
- suppressor of cytokine signalling 2
- suppressor of cytokine signaling 2
- suppressor of cytokine signaling 2 variant 1
- CASP2 and RIPK1 domain containing adaptor with death domain
- death domain-containing protein CRADD
- suppressor of cytokine signaling 2 S homeolog
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