SMURF2 抗体
(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
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70 results :
SMURF2
适用: 人, 小鼠, 大鼠
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
宿主: 兔
Polyclonal
unconjugated
1 reference
SMURF2
适用: 人, 大鼠
WB, IF, IHC (p)
宿主: 兔
Polyclonal
RB4107-4108
unconjugated
1 reference
SMURF2
适用: 人, 小鼠, 大鼠
WB, ELISA, IHC, IF, ICC
宿主: 兔
Polyclonal
unconjugated
SMURF2
适用: 人, 小鼠, 大鼠
WB, FACS, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 750
SMURF2
适用: 人, 小鼠, 大鼠
WB, FACS, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 680
SMURF2
适用: 人, 小鼠, 大鼠
WB, FACS, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 594
SMURF2
适用: 人, 小鼠, 大鼠
WB, FACS, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 350
SMURF2
适用: 人, 小鼠, 大鼠
WB, FACS, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 488
SMURF2
适用: 人, 小鼠, 大鼠
WB, FACS, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 647
SMURF2
适用: 人, 小鼠, 大鼠
WB, FACS, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 555
SMURF2
适用: 人, 小鼠, 大鼠
WB, ELISA, IHC (p), IHC (fro)
宿主: 兔
Polyclonal
HRP
SMURF2
适用: 人, 小鼠, 大鼠
WB, FACS, IF (cc), IF (p)
宿主: 兔
Polyclonal
Cy5.5
Latest Publications for our SMURF2 抗体
: "TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2." in: Cell death and differentiation, (2019) (PubMed).: "Human trabecular meshwork cells express BMP antagonist mRNAs and proteins." in: Experimental eye research, Vol. 147, pp. 156-60, (2016) (PubMed).
: "The proteasome inhibitor, MG132, attenuates diabetic nephropathy by inhibiting SnoN degradation in vivo and in vitro." in: BioMed research international, Vol. 2014, pp. 684765, (2015) (PubMed).
: "Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-? inhibition of mesenchymal stem cell osteogenic differentiation." in: PLoS ONE, Vol. 7, Issue 3, pp. e31717, (2012) (PubMed).
: "The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." in: The Journal of biological chemistry, Vol. 282, Issue 48, pp. 35259-68, (2007) (PubMed).
: "Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." in: The EMBO journal, Vol. 26, Issue 5, pp. 1410-22, (2007) (PubMed).
: "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 3, pp. 974-9, (2001) (PubMed).
: "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation." in: Molecular cell, Vol. 6, Issue 6, pp. 1365-75, (2001) (PubMed).
: "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling." in: The Journal of biological chemistry, Vol. 275, Issue 47, pp. 36818-22, (2001) (PubMed).
Aliases for SMURF2 抗体
SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) 抗体SMAD specific E3 ubiquitin protein ligase 2 (smurf2) 抗体
SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) 抗体
SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S) 抗体
2810411E22Rik 抗体
AI558114 抗体
AI649275 抗体
RGD1310067 抗体
SMURF2 抗体
wu:fb82a11 抗体
wu:fc41c02 抗体
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