(Solute Carrier Family 29 (Nucleoside Transporters), Member 1 (SLC29A1))
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
Greenhalf, Ghaneh, Neoptolemos, Palmer, Cox, Lamb, Garner, Campbell, Mackey, Costello, Moore, Valle, McDonald, Carter, Tebbutt, Goldstein, Shannon, Dervenis, Glimelius, Deakin, Charnley, Lacaine et al.: "Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial. ..." in: Journal of the National Cancer Institute, Vol. 106, Issue 1, pp. djt347, (2014) (PubMed).
Aliases for SLC29A1 蛋白
solute carrier family 29 member 1 (Augustine blood group) (SLC29A1) 蛋白 solute carrier family 29 member 1 (Slc29a1) 蛋白 solute carrier family 29 (nucleoside transporters), member 1 (Slc29a1) 蛋白 1200014D21Rik 蛋白 AA407560 蛋白 ENT1 蛋白 rENT1 蛋白