SLC22A1 产品
(Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1))
Categories
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008].
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Featured SLC22A1 Categories
SLC22A1 抗体
High quality antibodies with extensive validation data.
SLC22A1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
SLC22A1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SLC22A1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7075663
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (3)
- (2)
Cat. No.
ABIN969400
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7170131
Quantity
100 μg
Datasheet
Datasheet
Recommended SLC22A1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative DNA-Binding ELISA
Validations
Cat. No.
ABIN5648541
Quantity
96 tests
Datasheet
Datasheet
Recommended SLC22A1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3109816
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3095212
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3131352
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SLC22A1 Products
: "Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB)." in: PLoS ONE, Vol. 12, Issue 3, pp. e0173474, (2017) (PubMed).: "Organic anion transporting polypeptide 1B3 can form homo- and hetero-oligomers." in: PLoS ONE, Vol. 12, Issue 6, pp. e0180257, (2017) (PubMed).
: "Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport." in: American journal of human genetics, Vol. 101, Issue 4, pp. 489-502, (2017) (PubMed).
: "The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin." in: Scientific reports, Vol. 6, pp. 20508, (2016) (PubMed).
: "Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1." in: Genome medicine, Vol. 7, Issue 1, pp. 56, (2015) (PubMed).
: "The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier." in: Molecular pharmaceutics, Vol. 11, Issue 3, pp. 995-1006, (2014) (PubMed).
: "Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 42, Issue 6, pp. 990-5, (2014) (PubMed).
: "OCT1 (SLC22A1) R61C polymorphism and response to imatinib treatment in chronic myeloid leukemia patients." in: Leukemia & lymphoma, Vol. 49, Issue 11, pp. 2222-3, (2008) (PubMed).
: "Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells." in: Pharmaceutical research, Vol. 25, Issue 4, pp. 827-35, (2008) (PubMed).
: "Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia." in: Blood, Vol. 112, Issue 8, pp. 3348-54, (2008) (PubMed).
Synonyms and alternative names related to SLC22A1
solute carrier family 22 member 1 (SLC22A1), solute carrier family 22 (organic cation transporter), member 1 (Slc22a1), solute carrier family 22 member 1 (Slc22a1), solute carrier family 22 member 2-like (LOC421584), HOCT1, Lx1, OCT1, Oct1, oct1_cds, Orct, Orct1, Roct1, SLC22A1, SLC22A2Protein level used designations for SLC22A1
- solute carrier family 22 member 1
- solute carrier family 22 (organic cation transporter), member 1
- solute carrier family 22 member 1-like
- pOCT1
- organic cation transporter 1
- mOCT1
- solute carrier family 22, member 1
- solute carrier family 22 (organic cation transporter), member 2
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