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SLC12A3 产品

(Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3))
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured SLC12A3 Categories

SLC12A3 抗体

High quality antibodies with extensive validation data.

SLC12A3 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

SLC12A3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SLC12A3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application WB, IHC, ICC, IF, IEM
Validations
  • (10)
  • (7)
Cat. No. ABIN863201
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (9)
Cat. No. ABIN7435784
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (8)
Cat. No. ABIN7441745
Quantity 100 μL
Datasheet Datasheet

Recommended SLC12A3 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
Cat. No. ABIN6720503
Quantity 96 tests
Datasheet Datasheet

Recommended SLC12A3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3113965
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7401062
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7397996
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SLC12A3 Products

Hariharan, Reinke, Kurtz: "Generating Multiple Kidney Progenitors and Cell Types from Human Pluripotent Stem Cells." in: Methods in molecular biology (Clifton, N.J.), Vol. 1926, pp. 103-115, (2019) (PubMed).

Lu, Rudemiller, Wen, Ren, Hammer, Griffiths, Privratsky, Yang, Sparks, Crowley: "A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation." in: Circulation research, Vol. 125, Issue 12, pp. 1055-1066, (2019) (PubMed).

Duan, Gu, Xiao, Gao, Wu, Zhang, Meng, Wang, Zhang, Lin, Wang, Gu: "Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule." in: Hypertension (Dallas, Tex. : 1979), Vol. 73, Issue 1, pp. 112-120, (2019) (PubMed).

Fenton, Poulsen, de la Mora Chavez, Soleimani, Dominguez Rieg, Rieg: "Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis." in: Kidney international, Vol. 92, Issue 2, pp. 397-414, (2018) (PubMed).

Procino, Carmosino, Milano, Dal Monte, Schena, Mastrodonato, Gerbino, Bagnoli, Svelto: "β3 adrenergic receptor in the kidney may be a new player in sympathetic regulation of renal function." in: Kidney international, Vol. 90, Issue 3, pp. 555-67, (2017) (PubMed).

Turco, Lam, Rule, Denic, Lieske, Miller, Larson, Kremers, Jayachandran: "Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys." in: Journal of extracellular vesicles, Vol. 5, pp. 29642, (2016) (PubMed).

Patel-Chamberlin, Varasteh Kia, Xu, Barone, Zahedi, Soleimani: "The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation." in: PLoS ONE, Vol. 11, Issue 3, pp. e0150918, (2016) (PubMed).

Gois, Canale, Luchi, Volpini, Veras, Costa, Shimizu, Seguro: "Tenofovir during pregnancy in rats: a novel pathway for programmed hypertension in the offspring." in: The Journal of antimicrobial chemotherapy, Vol. 70, Issue 4, pp. 1094-105, (2015) (PubMed).

Wen, Yuan, Warner, Wang, Cornelius, Wang-France, Li, Boettger, Sansom: "Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency." in: Hypertension, Vol. 66, Issue 1, pp. 68-74, (2015) (PubMed).

Cheng, Wu, Kortenoeven, Pisitkun, Fenton: "A Systems Level Analysis of Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells." in: Scientific reports, Vol. 5, pp. 12829, (2015) (PubMed).

Synonyms and alternative names related to SLC12A3

solute carrier family 12 member 3 (SLC12A3), solute carrier family 12 (sodium/chloride transporter), member 3 (slc12a3.2), solute carrier family 12 member 3 (Slc12a3), solute carrier family 12, member 3 (Slc12a3), AI035291, DKFZp469N2315, NCC, NCCT, SLC12A3, slc12a3, TSC

Protein level used designations for SLC12A3

  • solute carrier family 12 (sodium/chloride transporters), member 3
  • thiazide-sensitive sodium chloride cotransporter
  • solute carrier family 12 (sodium/chloride transporters), member 3, gene 2
  • solute carrier family 12 member 3-like
  • Na-Cl cotransporter
  • Na-Cl symporter
  • NaCl electroneutral thiazide-sensitive cotransporter
  • solute carrier family 12 member 3
  • thiazide-sensitive Na-Cl cotransporter
  • thiazide-sensitive sodium-chloride cotransporter
  • solute carrier family 12, member 3
  • sodium chloride cotransporter
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