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Human Monoclonal SH2D2A Primary Antibody for FACS, IF - ABIN2731958
Pandya, Leergaard, Dissen, Haraldsen, Spurkland: Expression of the T cell-specific adapter protein in human tissues. in Scandinavian journal of immunology 2014
Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen and linker for activation of T cells protein (LAT) phosphotyrosine (pTyr) peptides.
TSAD binds to and co-localizes with Nck. Expression of TSAD increases both Nck-Lck and Nck-SLP-76 interaction in T cells.
The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Data indicate the expression pattern of T cell-specific adapter protein (TSAd) in various healthy lymphoid and non-lymphoid tissues.
in chronic inflammatory demyelinating polyneuropathy we found an association with a homozygous genotype for a low repeat number of tandem GA in the SH2D2A gene
TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements
TSAd associates with laminin binding protein and mediates T lymphocyte migration during T cell activation
'short' alleles of the promoter could contribute to the genetic susceptibility to Juvenile Rheumatoid Arthritis
TSAd appears to contribute to interleukin-2 synthesis at multiple different levels
upon chemokine stimulation, Lad acts as an adaptor protein that links the G protein beta subunit to the tyrosine kinases Lck and Zap-70, thereby mediating T-cell migration
SH2D2A expression is regulated both at the transcriptional and translational level.
This study found a significant association between CIDP and the genotype GA13-16 homozygote (OR 3.167; p 0.013).
lymphocyte-specific protein tyrosine kinase binds to T cell-specific adapter protein (TSAd) prolines and phosphorylates and interacts with the three C-terminal TSAd tyrosines
the present study shows that the SH2D2A gene may contribute to susceptibility to MS.
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants.
SH2 domain protein 2A
, SH2 domain-containing protein 2A
, T cell specific adapter protein TSAd
, T lymphocyte specific adaptor protein
, VEGF receptor-associated protein
, Lck-associated adapter protein
, Rlk/Itk-binding protein
, T cell-specific adapter protein
, p56Lck-associated adapter protein