SIP1 产品
(Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2))
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This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011].
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Recommended SIP1 抗体
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Reactivity
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Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IHC (p)
Validations
- (4)
Cat. No.
ABIN625932
Quantity
0.05 mg
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Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP
Validations
- (3)
Cat. No.
ABIN7153753
Quantity
100 μg
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Reactivity
Human, Mouse, Xenopus laevis
Application
WB, ELISA, IF, IP, ICC, FACS
Validations
- (8)
- (2)
Cat. No.
ABIN108540
Quantity
0.1 mL
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Datasheet
Recommended SIP1 ELISA试剂盒
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Reactivity
Analytical Method
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Quantity
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Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6231037
Quantity
96 tests
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Recommended SIP1 蛋白
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Source
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Quantity
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Mouse
Source
HEK-293 Cells
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- (3)
Cat. No.
ABIN7560565
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
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- (3)
Cat. No.
ABIN7547972
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Cell-free protein synthesis (CFPS)
Validations
Cat. No.
ABIN3080724
Quantity
0.5 mg
Datasheet
Datasheet
Latest Publications for our SIP1 Products
: "ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma." in: Genes & cancer, Vol. 4, Issue 11-12, pp. 486-500, (2014) (PubMed).: "JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines." in: PLoS ONE, Vol. 9, Issue 12, pp. e115684, (2014) (PubMed).
: "A novel function for the survival motoneuron protein as a translational regulator." in: Human molecular genetics, Vol. 22, Issue 4, pp. 668-84, (2013) (PubMed).
: "Proteomic assessment of a cell model of spinal muscular atrophy." in: BMC neuroscience, Vol. 12, pp. 25, (2011) (PubMed).
: "GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination." in: Nucleic acids research, Vol. 38, Issue 15, pp. 5059-74, (2010) (PubMed).
: "Novel monoclonal antibodies detect Smad-interacting protein 1 (SIP1) in the cytoplasm of human cells from multiple tumor tissue arrays." in: Experimental and molecular pathology, Vol. 89, Issue 2, pp. 182-9, (2010) (PubMed).
: "Regulation of SMN protein stability." in: Molecular and cellular biology, Vol. 29, Issue 5, pp. 1107-15, (2009) (PubMed).
: "SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain." in: Human molecular genetics, Vol. 17, Issue 21, pp. 3399-410, (2008) (PubMed).
: "A novel cell response triggered by interphase centromere structural instability." in: The Journal of cell biology, Vol. 177, Issue 5, pp. 757-68, (2007) (PubMed).
: "Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 4, pp. 680-92, (2006) (PubMed).
Synonyms and alternative names related to SIP1
gem nuclear organelle associated protein 2 (GEMIN2), gem nuclear organelle associated protein 2 (Gemin2), gem (nuclear organelle) associated protein 2 (Gemin2), gem nuclear organelle associated protein 2 S homeolog (gemin2.S), gem (nuclear organelle) associated protein 2 (gemin2), 1700012N19Rik, SIP1, Sip1, sip1, SIP1-delta, sip1-delta, wu:fc52a05, zgc:110274Protein level used designations for SIP1
- SMN interacting protein 1-delta
- component of gems 2
- gem-associated protein 2
- gemin-2
- survival of motor neuron protein interacting protein 1
- SMN-interacting protein 1
- survival of motor neuron protein-interacting protein 1
- survivor of motor neuron protein interacting protein 1
- SMN interacting protein-1
- Survival of motor neuron protein-interacting protein 1
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