Shugoshin 产品
(Shugoshin 1 (SGOL1))
Categories
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.
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Featured Shugoshin Categories
Shugoshin 抗体
High quality antibodies with extensive validation data.
Shugoshin 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Shugoshin 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IP
Validations
- (9)
- (4)
Cat. No.
ABIN566873
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IF
Validations
- (3)
Cat. No.
ABIN7169545
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Schizosaccharomyces pombe
Application
WB, IF
Validations
- (3)
- (3)
Cat. No.
ABIN2452123
Quantity
100 μL
Datasheet
Datasheet
Recommended Shugoshin ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648311
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6233627
Quantity
96 tests
Datasheet
Datasheet
Recommended Shugoshin 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7564961
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7555476
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2731936
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our Shugoshin Products
: "Negative feedback at kinetochores underlies a responsive spindle checkpoint signal." in: Nature cell biology, Vol. 16, Issue 12, pp. 1257-64, (2014) (PubMed).: "B56? tumor-associated mutations provide new mechanisms for B56?-PP2A tumor suppressor activity." in: Molecular cancer research : MCR, Vol. 11, Issue 9, pp. 995-1003, (2013) (PubMed).
: "Centromere DNA decatenation depends on cohesin removal and is required for mammalian cell division." in: Journal of cell science, Vol. 123, Issue Pt 5, pp. 806-13, (2010) (PubMed).
: "A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A." in: Oncogene, Vol. 29, Issue 27, pp. 3933-41, (2010) (PubMed).
: "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation." in: Nature cell biology, Vol. 12, Issue 7, pp. 719-27, (2010) (PubMed).
: "Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes." in: Human reproduction (Oxford, England), Vol. 25, Issue 9, pp. 2316-27, (2010) (PubMed).
: "Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase." in: The Journal of cell biology, Vol. 187, Issue 6, pp. 781-90, (2009) (PubMed).
: "Heterochromatin links to centromeric protection by recruiting shugoshin." in: Nature, Vol. 455, Issue 7210, pp. 251-5, (2008) (PubMed).
: "Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis." in: Cell research, Vol. 17, Issue 7, pp. 608-18, (2007) (PubMed).
: "Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity." in: The Journal of cell biology, Vol. 178, Issue 3, pp. 345-54, (2007) (PubMed).
Synonyms and alternative names related to Shugoshin
shugoshin 1 (Sgo1), shugoshin centromeric cohesion 1 (sgo1), shugoshin 1 L homeolog (sgo1.L), shugoshin 1 (SGO1), 3300001M08Rik, C81037, NY-BR-85, SGO, sgo1, Sgo1Protein level used designations for Shugoshin
- AY109536_SNP
- CL5684_1
- CL5684_1_ov
- gnp_AW055587
- gpm134
- p-std614083G09
- shugoshin-1
- shugoshin-like protein
- shugosin centromeric cohesion1
- std614083G09
- zmSGO1
- xsgo
- hSgo1
- serologically defined breast cancer antigen NY-BR-85
- shugoshin 1AB protein
- shugoshin 1CD protein
- shugoshin 1EF protein
- shugoshin 1GH protein
- shugoshin 1KL protein
- shugoshin-like 1
- shugoshin 1A protein
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