This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010].
Yi, Chen, Wu, Yang, Xu, Zhuang, Han, Xu: "Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 239, Issue 7, pp. 2005-13, (2010) (PubMed).
Lozada, Karlstedt, Panula, Aarnisalo: "Unilateral labyrinthectomy induced changes on GDNF receptor complex proteins in the rat medial vestibular nuclei." in: Journal of vestibular research : equilibrium & orientation, Vol. 16, Issue 4-5, pp. 171-7, (2007) (PubMed).
He, Jiang, Hofmann, Dym: "Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase." in: Biology of reproduction, Vol. 77, Issue 4, pp. 723-33, (2007) (PubMed).
Aliases for SHoc2/Sur8 抗体
soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2) 抗体 SHOC2 leucine-rich repeat scaffold protein (Shoc2) 抗体 SHOC2 leucine-rich repeat scaffold protein S homeolog (shoc2.S) 抗体 SHOC2, leucine rich repeat scaffold protein (SHOC2) 抗体 SHOC2 leucine-rich repeat scaffold protein (shoc2) 抗体 AU017287 抗体 mKIAA0862 抗体 si:ch211-159c12.3 抗体 si:ch211-197i12.3 抗体 SIAA0862 抗体 SOC2 抗体 Sur8 抗体 SUR8 抗体 zgc:152956 抗体