SH2B3 产品
(SH2B Adaptor Protein 3 (SH2B3))
Categories
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq, May 2010].
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Featured SH2B3 Categories
Recommended SH2B3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (2)
Cat. No.
ABIN6243723
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN185272
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, ICC
Validations
- (1)
Cat. No.
ABIN6265048
Quantity
100 μL
Datasheet
Datasheet
Recommended SH2B3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3077021
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3131375
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405777
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SH2B3 Products
: "CXM: a new tool for mapping breast cancer risk in the tumor microenvironment." in: Cancer research, Vol. 74, Issue 22, pp. 6419-29, (2014) (PubMed).: "Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F." in: Journal of leukocyte biology, Vol. 85, Issue 6, pp. 957-65, (2009) (PubMed).
: "Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders." in: Blood, Vol. 110, Issue 9, pp. 3360-4, (2007) (PubMed).
: "The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways." in: The Journal of biological chemistry, Vol. 281, Issue 29, pp. 20148-59, (2006) (PubMed).
: "Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis." in: The Journal of experimental medicine, Vol. 200, Issue 5, pp. 569-80, (2004) (PubMed).
: "Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 10, pp. 5199-206, (2000) (PubMed).
Synonyms and alternative names related to SH2B3
SH2B adaptor protein 3 (SH2B3), SH2B adaptor protein 3 (Sh2b3), AI429800, IDDM20, LNK, LnkProtein level used designations for SH2B3
- lymphocyte adaptor protein
- SH2B adapter protein 3
- lymphocyte-specific adapter protein Lnk
- signal transduction protein Lnk
- linker of T-cell receptor pathways
- lymphocyte adapter protein
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