SH2B2 抗体
(SH2B Adaptor Protein 2 (SH2B2))
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009].
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Latest Publications for our SH2B2 抗体
: "Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling." in: Endocrinology, Vol. 148, Issue 4, pp. 1615-21, (2007) (PubMed).: "Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588." in: The Journal of biological chemistry, Vol. 280, Issue 45, pp. 37827-32, (2005) (PubMed).
: "APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation." in: Biochemical and biophysical research communications, Vol. 330, Issue 3, pp. 1005-13, (2005) (PubMed).
Aliases for SH2B2 抗体
SH2B adaptor protein 2 (SH2B2) 抗体SH2B adaptor protein 2 (Sh2b2) 抗体
APS 抗体
Aps 抗体
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