This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011].
Klinkenberg, Long, Shome, Watkins, Aridor: "A cascade of ER exit site assembly that is regulated by p125A and lipid signals." in: Journal of cell science, Vol. 127, Issue Pt 8, pp. 1765-78, (2014) (PubMed).
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
Perry, Moschos, Williams, Shepherd, Larner-Svensson, Lindsay: "Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 8, pp. 5689-98, (2008) (PubMed).
Huttunen, Guénette, Peach, Greco, Xia, Kim, Barren, Tanzi, Kovacs: "HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation." in: The Journal of biological chemistry, Vol. 282, Issue 38, pp. 28285-95, (2007) (PubMed).
Aliases for SEC23IP 抗体
SEC23 interacting protein (Sec23ip) 抗体 SEC23 interacting protein (SEC23IP) 抗体 SEC23 interacting protein (sec23ip) 抗体 Phosphatidic Acid Phospholipase A1 (PAPLA1) 抗体 SEC23 interacting protein S homeolog (sec23ip.S) 抗体 Sec23 interacting protein (Sec23ip) 抗体 CG14278 抗体 D7Ertd373e 抗体 DKFZp469D0613 抗体 Dmel\\CG8552 抗体 P125 抗体 p125 抗体 P125A 抗体 Sec23-IP 抗体 si:dkey-192p21.3 抗体 wu:fa20e07 抗体 zgc:152883 抗体