This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008].
Licht, Tsirulnikov, Reuveni, Yarnitzky, Ben-Sasson: "Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3)." in: Blood, Vol. 102, Issue 6, pp. 2099-107, (2003) (PubMed).
An, Zheng, Bleu: "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5." in: The Journal of biological chemistry, Vol. 275, Issue 1, pp. 288-96, (2000) (PubMed).
Himmel, Meyer Zu Heringdorf, Graf, Dobrev, Kortner, Schüler, Jakobs, Ravens: "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes." in: Molecular pharmacology, Vol. 58, Issue 2, pp. 449-54, (2000) (PubMed).