SARS-CoV-2 Spike S1 蛋白
(SARS-CoV-2 Spike S1)
attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
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90 results
宿主: SARS Coronavirus-2 (SARS-CoV-2)
宿主: 大肠杆菌（E. Coli）
Recombinant
>95 %
宿主: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Kappa
宿主: HEK-293 Cells
Recombinant
>95 % as determined by reduced SDS-PAGE.
Active
宿主: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Delta
宿主: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Active
宿主: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Omicron
宿主: HEK-293 Cells
Recombinant
95,00 %
宿主: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Omicron
宿主: HEK-293 Cells
Recombinant
95,00 %
宿主: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Omicron
宿主: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
宿主: SARS Coronavirus-2 (SARS-CoV-2)
宿主: HEK-293 Cells
Recombinant
> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
WB, ELISA
宿主: SARS Coronavirus-2 (SARS-CoV-2)
宿主: HEK-293 Cells
Recombinant
> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
WB, ELISA
宿主: SARS Coronavirus-2 (SARS-CoV-2)
宿主: 人细胞
Recombinant
>95% as determined by SDS-PAGE.
WB, ELISA
宿主: SARS Coronavirus-2 (SARS-CoV-2)
宿主: HEK-293 Cells
Recombinant
> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
WB, ELISA
Latest Publications for our SARS-CoV-2 Spike S1 蛋白
: "Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease." in: Brain, behavior, and immunity, Vol. 109, pp. 251-268, (2023) (PubMed).: "Point-of-care (POC) SARS-CoV-2 antigen detection using functionalized aerosol jet-printed organic electrochemical transistors (OECTs)." in: Nanoscale, Vol. 15, Issue 11, pp. 5476-5485, (2023) (PubMed).
: "Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection." in: Stroke, Vol. 52, Issue 1, pp. 260-270, (2021) (PubMed).
: "Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 5, (2021) (PubMed).
: "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus." in: Communications biology, Vol. 4, Issue 1, pp. 129, (2021) (PubMed).
: "Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction." in: Journal of the American Society for Mass Spectrometry, (2021) (PubMed).
: "Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum." in: ACS infectious diseases, (2021) (PubMed).
: "Delayed production of neutralizing antibodies correlates with fatal COVID-19. ..." in: Nature medicine, (2021) (PubMed).
: "Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. ..." in: Cell reports. Medicine, pp. 100288, (2021) (PubMed).
: "A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. ..." in: Nature communications, Vol. 12, Issue 1, pp. 2623, (2021) (PubMed).
Aliases for SARS-CoV-2 Spike S1 蛋白
Surface Glycoprotein (S) 蛋白E2 蛋白
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